35576-46-6

Upstream product

• 1516-37-6 1-(2-methoxyphenyl)thiourea 
• 74-88-4 methyl iodide 
• 90-04-0 2-methoxy-phenylamine 
• 21258-10-6 N-benzoyl- N′-(2-methoxyphenyl)thiourea 

Downstream Products

• 80306-56-5 3-(2-methoxyphenyl)-2-methylthio-4(3H)-pyrimidinone 
• 82636-18-8 1-(2-Methoxy-phenyl)-2-methylsulfanyl-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 82635-91-4 2-[3-(2-Methoxy-phenyl)-2-methyl-isothioureidomethylene]-malonic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis & Pharmacological Evaluation of Ethyl 3-Substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates

A number of ethyl 3-substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates (V) have been prepared by the reaction of amidines (III) with diethyl ethoxymethylenemalonate.In order to confirm the structure (V), ethyl 3-(2'-methylphenyl)-2-methylmercapto-4(3H)pyrimidone-5-carboxylate (103) has been transformed into the earlier synthesised 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone (115) by decarboxylation of 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone-5-carboxylic acid (114), obtained by the alkaline hydrolysis of 103.Someof these compounds have shown antiinflammatory, diuretic and antipassive cutaneous anaphylaxis activities.