35578-28-0

Basic information

• Product Name: 3-Chloropropane-1-sulfonaMide
• Synonyms: 3-Chloropropane-1-sulfonaMide;3-chloro-1-Propanesulfonamide
• CAS NO: 35578-28-0
• Molecular Formula: C₃H₈ClNO₂S
• Molecular Weight: 157.61912
• Mol File: 35578-28-0.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Chloropropane-1-sulfonaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloropropane-1-sulfonaMide(35578-28-0)
• EPA Substance Registry System: 3-Chloropropane-1-sulfonaMide(35578-28-0)

Safety Data

• Hazardous Substances Data: 35578-28-0(Hazardous Substances Data)

Usage

General Description

3-Chloropropane-1-sulfonamide is a chemical compound with the molecular formula C3H7ClNO2S. It is a sulfonamide derivative of 3-chloropropanol and is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals. 3-Chloropropane-1-sulfonamide is also utilized in organic synthesis as a precursor for the preparation of various compounds. It is a white solid that is soluble in water and other organic solvents. The compound is classified as a hazardous material, and proper safety measures should be taken when handling it.

Upstream product

• 24243-71-8 propane-1-sulfonamide 
• 1120-71-4 1,3-propanesultone 
• 1633-82-5 3-chloro-n-propanesulfonyl chloride 

Downstream Products

• 1034192-12-5 3-azidopropane-1-sulfonamide 
• 1383851-90-8 3-{[3-cyano-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-6-yl](methylsulfonyl)amino}propane-1-sulfonamide 
• 1236765-84-6 3-({4-Oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-4,5-dihydro-3h-pyrrolo[3,2-d]pyrimidin-2-yl}sulfanyl)propane-1-sulfonamide 
• 383661-65-2 3-phenylthiopropanesulfonamide 
• 317334-52-4 1-[3-(1,1-dioxo-isothiazolin-2-ylmethyl)-5-(pyridin-2-yl-methyl)phenyl]ethanone 

Relevant articles and documents

Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation

Multivalency has impressive effects on (bio)molecular recognition, through the simultaneous presentation of multiple copies of a ligand, which can change a weak millimolar binder into a potent nanomolar one. The implementation of multivalency in enzyme inhibition is rather recent, being exemplified by few serendipitous discoveries, and hitherto relying on the random exploration of new multivalent structures as potential enzyme inhibitors. Here, a straightforward and versatile method is reported that enables the construction of multivalent systems for the inhibition of carbonic anhydrases (CA), widespread enzymes that catalyze a fundamental biochemical reaction. Oxime and hydrazone click-type bioconjugation techniques were successfully used for the preparation of tetravalent peptide conjugates tethered with sulfonamide CA inhibitors. The enzyme inhibition assays show that multivalent effects were present with these novel compounds, but also reveal various structural effects provided by the scaffolds. The versatility of this approach may facilitate the exploration of structure–activity relationships for other types of enzyme inhibitors.

MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS

There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, util

NOVEL PYRIDINE DERIVATIVES

The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.