355841-11-1Relevant articles and documents
Synthetic method of benzofluorenol-D9
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, (2020/07/13)
The invention provides a synthesis method of benzofluorenol-D9, which comprises the following steps: 1) in the presence of anhydrous aluminum chloride, carrying out Friedel-Crafts reaction on a compound 1 and chloroacetyl chloride to obtain a compound 2; 2) performing reduction reaction on the compound 2 and sodium borohydride to obtain a compound 3; 3) performing substitution reaction on the compound 3 and n-butylamine to obtain a compound 4; 4) in the presence of alkali, carrying out condensation reaction on the compound 4 and p-chlorobenzaldehyde to prepare a compound 5; and 5) in the presence of potassium carbonate, subjecting the compound 5 and deuterated n-bromobutane-D9 to a substitution reaction so as to prepare benzofluorenol-D9. According to the method, the commercially availabledeuterated n-bromobutane-D9 is used as the deuterated raw material for the first time, the deuterated benzofluorenol-D9 is finally synthesized through a series of reactions, use of di-n-butylamine-D9is avoided, the deuterated raw material with high price is used as the last step of reaction raw material in the route, and cost reduction is facilitated.
