355841-11-1Relevant academic research and scientific papers
Synthetic method of benzofluorenol-D9
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, (2020/07/13)
The invention provides a synthesis method of benzofluorenol-D9, which comprises the following steps: 1) in the presence of anhydrous aluminum chloride, carrying out Friedel-Crafts reaction on a compound 1 and chloroacetyl chloride to obtain a compound 2; 2) performing reduction reaction on the compound 2 and sodium borohydride to obtain a compound 3; 3) performing substitution reaction on the compound 3 and n-butylamine to obtain a compound 4; 4) in the presence of alkali, carrying out condensation reaction on the compound 4 and p-chlorobenzaldehyde to prepare a compound 5; and 5) in the presence of potassium carbonate, subjecting the compound 5 and deuterated n-bromobutane-D9 to a substitution reaction so as to prepare benzofluorenol-D9. According to the method, the commercially availabledeuterated n-bromobutane-D9 is used as the deuterated raw material for the first time, the deuterated benzofluorenol-D9 is finally synthesized through a series of reactions, use of di-n-butylamine-D9is avoided, the deuterated raw material with high price is used as the last step of reaction raw material in the route, and cost reduction is facilitated.
Benflumetol derivatives, intermediates thereof and their use against parasitical protozoa and trematodes
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, (2008/06/13)
The invention relates to a compound of formula (1), wherein R is an alkyl unsubstituted by one or more polar substituents or an alkenyl unsubstituted or substituted by one or more polar substituents, and X is aryl, or salts thereof. The compounds are effe
