355860-80-9Relevant academic research and scientific papers
Simple preparation method of 4-substituted methyl-1-(2H)-phthalazinone
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Paragraph 0081-0082, (2019/08/30)
The invention provides a simple preparation method of 4-substituted methyl-1-(2H)-phthalazinone (I). According to the method, condensation is carried out on a two G substituted benzene (II) and a compound represented by a formula III in the presence of a solvent A and an alkali, a compound represented by a formula IV is obtained through hydrolysis, and then, condensation is carried out on the compound represented by the formula IV or an esterification product of the compound represented by the formula IV and hydrazine hydrate to prepare 4-(pyridin-4-yl)-methyl-1-(2H)-phthalazinone (IA) or 4-(4-fluoro-3-carboxyphenyl)methyl-1-(2H)-phthalazinone (IB) which can be used for preparing vatalanib and olaparib. The preparation method is simple and convenient in technological process, is high in reaction reproducibility, is easy to operate, and is good in product stability and high in purity.
