35593-63-6Relevant academic research and scientific papers
Tandem palladium-catalyzed allene arylation and oxazoline formation
Cook, Gregory R.,Xu, Wei
, p. 215 - 232 (2007/10/03)
The tandem palladium-catalyzed addition of aryl iodides to allenes followed by cyclization to afford oxazolines was investigated. A variety of chiral 5-vinyloxazolines were obtained in high yield with excellent stereoselectivity via equilibration of the i
A practical approach to the synthesis of 2,4-disubstituted oxazoles from amino acids
Morwick, Tina,Hrapchak, Matt,DeTuri, Molly,Campbell, Scot
, p. 2665 - 2668 (2007/10/03)
(Matrix presented) A new sequence for the synthesis of various 2,4-disubstituted oxazoles from α-amino acids is reported. The method is shown to be general and incorporates the reagent combination, triphenylphosphine/hexachloroethane, for cyclodehydration of intermediate α-acylamino aldehydes. Implementation of this reagent system for the conversion of α-acylamino ketones to oxazoles is briefly investigated.
