35600-62-5

Upstream product

• 50-00-0 formaldehyd 
• 2603-10-3 N-phenyl methyl carbamate 
• 62-53-3 aniline 

Downstream Products

• 40151-04-0 Methyl-N-methoxymethyl-N-phenyl carbamate 
• 40151-05-1 Methyl-N-ethoxymethyl-N-phenyl carbamate 
• 40151-43-7 Butylsulfanylmethyl-phenyl-carbamic acid methyl ester 
• 40151-48-2 [N-(2,4-Dichloro-phenyl)aminooxymethyl]-phenyl-carbamic acid methyl ester 
• 40151-01-7 Dithiocarbonic acid O-ethyl ester S-[(methoxycarbonyl-phenyl-amino)-methyl] ester 
• 50887-78-0 Dithiopropionic acid (methoxycarbonyl-phenyl-amino)-methyl ester 
• 40151-03-9 (4-Chloro-benzenesulfonylmethyl)-phenyl-carbamic acid methyl ester 
• 40151-44-8 (4-Chloro-phenylsulfanylmethyl)-phenyl-carbamic acid methyl ester 
• 40151-06-2 Methyl-N-isopropoxymethyl-N-phenyl carbamate 
• 40151-42-6 (2,4-Dichloro-phenoxymethyl)-phenyl-carbamic acid methyl ester 
• 40151-07-3 Butoxymethyl-phenyl-carbamic acid methyl ester 
• 900187-57-7 (4-nitro-phenoxymethyl)-phenyl-carbamic acid methyl ester 

Relevant academic research and scientific papers

CANNABINOID DERIVATIVES

This disclosure relates generally to cannabinoid derivatives, pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives.

N-Alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) prodrugs of carboxylic acid containing drugs

Synthesis and hydrolysis in aqueous buffers of novel N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) and N-aryl-N-alkyloxycarbonylaminomethyl (NArNAOCAM) derivatives of carboxylic acid containing drugs were carried out. The hydrolysis follows a SN1 type mechanism and is dependent on the nucleofugacity of the leaving group. Topical delivery of the NANAOCAM derivative of naproxen from IPM across hairless mice skin was examined in in vitro diffusion cell experiments. The prodrug was 4.5-fold less lipid soluble, 2.4-fold less water soluble and 3.6-fold less permeable than the parent drug.

Synthesis, hydrolyses and dermal delivery of N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) derivatives of phenol, imide and thiol containing drugs

Synthesis, characterization and hydrolysis in aqueous buffers of novel N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) derivatives of substituted phenols, theophylline (Th) and 6-mercaptopurine (6MP) were carried out. The mechanism of hydrolysis was further investigated by synthesis, characterization and hydrolysis of N-aryl-N-alkyloxycarbonylaminomethyl (NArNAOCAM) derivatives of phenols. The hydrolysis follows pseudounimolecular first order kinetics and operates by way of an SN1-type mechanism. Topical delivery of selected derivatives of acetaminophen (APAP), Th and 6MP was examined in in vitro diffusion cell experiments from IPM across hairless mice skins. The prodrug of APAP and 6MP increased permeation across the skin by about 2- and 4-fold, respectively, compared to the parent drug. NANAOCAM promoieties can act as novel prodrug derivatives of phenol, imide and thiol containing drugs for enhancing topical absorption.