356067-04-4Relevant articles and documents
Recognition-mediated regiocontrol of a dipolar cycloaddition reaction
Howell, Sarah J,Spencer, Neil,Philp, Douglas
, p. 4945 - 4954 (2001)
The rational design of a recognition-based system that is capable of accelerating and controlling the regiochemical outcome of a dipolar cycloaddition reaction between an azide and an alkyne is presented. The origins of the acceleration and control of the cycloaddition reactions are rationalized - using molecular mechanics calculations - in terms of the formation of a complex between the reagents which organizes and orients them prior to reaction.