356068-89-8

Basic information

• Product Name: 2-(2-aMino-5-fluorophenyl)acetohydrazide
• Synonyms: 2-(2-aMino-5-fluorophenyl)acetohydrazide
• CAS NO: 356068-89-8
• Molecular Formula: C₈H₁₀FN₃O
• Molecular Weight: 183.1829032
• Mol File: 356068-89-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-aMino-5-fluorophenyl)acetohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-aMino-5-fluorophenyl)acetohydrazide(356068-89-8)
• EPA Substance Registry System: 2-(2-aMino-5-fluorophenyl)acetohydrazide(356068-89-8)

Safety Data

• Hazardous Substances Data: 356068-89-8(Hazardous Substances Data)

Usage

Molecular weight

182.19 g/mol

Chemical class

Hydrazide derivative

Structure

An acetohydrazide moiety with a substituted fluorophenyl ring

Usage

Building block in organic synthesis and pharmaceutical research for the preparation of biologically active compounds

Value in drug discovery

Unique structure and properties make it a valuable tool in the development of new drugs.

Upstream product

• 443-69-6 5-fluoro-1H-indole-2,3-dione 

Downstream Products

• 56341-41-4 5-fluoroindol-2(3H)-one 

Relevant articles and documents

Treatment of excessive osteolysis with indolinone compounds

Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.

Combination therapy for the treatment of cancer

The present invention relates to methods for treatment or prevention of neoplasia disorders using protein tyrosine kinase inhibitors in combination with cyclooxygenase inhibitors, in particular cyclooxygenase-2 selective inhibitors.

Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives

The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.