356068-89-8Relevant academic research and scientific papers
Treatment of excessive osteolysis with indolinone compounds
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, (2008/06/13)
Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.
Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
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Page/Page column 20, (2010/02/08)
The present invention is directed to a class indolinone compounds, hexahydro-cyclohepta-pyrrole oxindoles, which are useful as protein kinase inhibitors.
Combination therapy for the treatment of cancer
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, (2008/06/13)
The present invention relates to methods for treatment or prevention of neoplasia disorders using protein tyrosine kinase inhibitors in combination with cyclooxygenase inhibitors, in particular cyclooxygenase-2 selective inhibitors.
Treatment of acute myeloid leukemia with indolinone compounds
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, (2008/06/13)
A method of treating acute myeloid leukemia in patient positive for FLT-3-ITD is described. The treatment is accomplished by administration of a compound of Formula I or II as defined herein.
Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
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, (2008/06/13)
The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
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, (2008/06/13)
The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
Pyrrole substituted 2-indolinone protein kinase inhibitors
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, (2008/06/13)
The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
