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CYCLOPENTYL-(2,4-DIMETHOXY-BENZYL)-AMINE, also known as N-(2,4-Dimethoxybenzyl)cyclopentanamine, is an organic compound with a cyclopentyl amine core and a 2,4-dimethoxybenzyl group attached to it. This unique structure endows it with specific chemical properties and potential applications in various fields.

356092-74-5

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356092-74-5 Usage

Uses

Used in Pharmaceutical Industry:
CYCLOPENTYL-(2,4-DIMETHOXY-BENZYL)-AMINE is used as a reactant in the preparation of heteroarylsulfonamides. These heteroarylsulfonamides serve as acetyl-lysine mimetics, which are crucial for BET bromodomain inhibition. Bromodomain and extra-terminal (BET) proteins play a significant role in regulating gene expression, and their inhibition can have therapeutic effects in various diseases, including cancer and inflammatory disorders. By participating in the synthesis of these heteroarylsulfonamides, CYCLOPENTYL-(2,4-DIMETHOXY-BENZYL)-AMINE contributes to the development of novel therapeutic agents targeting BET bromodomain proteins.

Check Digit Verification of cas no

The CAS Registry Mumber 356092-74-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,6,0,9 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 356092-74:
(8*3)+(7*5)+(6*6)+(5*0)+(4*9)+(3*2)+(2*7)+(1*4)=155
155 % 10 = 5
So 356092-74-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H21NO2/c1-16-13-8-7-11(14(9-13)17-2)10-15-12-5-3-4-6-12/h7-9,12,15H,3-6,10H2,1-2H3

356092-74-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[(2,4-dimethoxyphenyl)methyl]cyclopentanamine

1.2 Other means of identification

Product number -
Other names N-(2,4-dimethoxybenzyl)cyclopentanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:356092-74-5 SDS

356092-74-5Downstream Products

356092-74-5Relevant academic research and scientific papers

Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition

Sharp, Phillip P.,Garnier, Jean-Marc,Huang, David C. S.,Burns, Christopher J.

supporting information, p. 1834 - 1842 (2015/01/08)

The ability of various functional groups to engage the acetyl-lysine (KAc) binding site within bromo- and extra-terminal domain (BET) protein family members BRD2, BRD3 and BRD4 was evaluated by screening small molecular fragments-coupled to a known arylsulfonamide scaffold-in biochemical inhibition assays. Useful structure activity relationships have been established and novel functional groups that bind to the KAc binding pocket identified. Additional microsomal degradation studies were also undertaken revealing significant differences in metabolic stability between two commonly employed BET inhibitor fragments.

PTERIDINE DERIVATIVES AND THEIR USE AS CATHESPIN INHIBITORS

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Page/Page column 19, (2008/06/13)

The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated wi

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