35629-70-0

Usage

Chemical Properties

Colorless to yellow solid

Synthesis Reference(s)

Journal of Medicinal Chemistry, 14, p. 1075, 1971 DOI: 10.1021/jm00293a014

InChI:InChI=1/C4H6N2O/c1-3-2-7-4(5)6-3/h2H,1H3,(H2,5,6)

Upstream product

• 57-13-6 urea 
• 598-31-2 1-bromoacetone 
• 420-04-2 CYANAMID 
• 116-09-6 hydroxy-2-propanone 

Downstream Products

• 35629-36-8 N-(4-methyl-1,3-oxazol-2-yl)acetamide 
• 55244-03-6 2-amino-4-methyl-N-phenyloxazole-5-carbothioamide 
• 57068-41-4 N-(2-methyl-butyl)-N-(4-methyl-oxazol-2-yl)-butyramide 
• 57069-30-4 N-(4-methyl-oxazol-2-yl)-2-phenyl-acetamide 
• 113304-35-1 2-amino-4-methyl-5-(α-hydroxy-4'-methoxy benzyl) oxazole 
• 117257-75-7 2-amino-4-methyl-5-(α-2'-dihydroxybenzyl)oxazole 
• 221089-41-4 1-(2-Chloro-6-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea 
• 221089-27-6 1-(5-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea 
• 221089-40-3 1-(4-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea 
• 226711-07-5 (4-methyl-oxazol-2-yl)-carbamic acid benzyl ester 
• 191019-22-4 2-imino-4-methyl-3-(4'-chlorophenacyl)-2,3-dihydrooxazole 

Relevant academic research and scientific papers

Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action

In this study, a novel series of CB2 receptor agonist imine derivatives, 1-6, was synthesized and evaluated for activity against the CB2 receptor. In a previous paper we reported the synthesis and SARs of thiazole derivative 1, a pot

Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: Selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

The design, synthesis, and biological evaluation of arylsulfonamidooxazoles as 11β-HSD1 inhibitors and the serendipitous discovery of β-keto sulfones as potent 11β-HSD1 inhibitors are described here. These two classes of compounds are not active against 11β-HSD2 and therefore may have significant therapeutic potential for metabolic syndrome, type 2 diabetes and related metabolic dysfunctions.

Formation of Thioamide Derivatives from Reactions of Isothiocyanates with Oxazol-2-amines

4-Substituted oxazol-2-amines react with isothiocyanates to give products having a thioamide function at C5.The reaction is considered to be an electrophilic process in competition with the usual reaction of the amino group with the isothiocyanate.The nature of the isothiocyanate and the type of substituent at C4 affect the amount of the thioamide product formed.Some chemical properties of the thioamides are also investigated.

Antianaphylactic agents. 1. 2-(Acylamino)oxazoles

The synthesis and biological properties of 35 2-(acylamino)oxazoles are described. The majority of the compounds inhibit the release of slow-reacting substance of anaphylaxis (SRS-A) in vitro from sensitized guinea pig chopped lung. In addition, several of the compounds inhibited the release of SRS-A from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.

Oxazole derivatives

A class novel 2,4 or 5-acylamino oxazoles having anti-allergic activity, methods of making such compounds and pharmaceutical compositions containing the active compounds of the invention. The compounds of the invention have been shown to be useful in the