35629-70-0

Basic information

• Product Name: 2-AMINO-4-METHYLOXAZOLE
• Synonyms: 2-AMINO-4-METHYLOXAZOLE;4-METHYL-1,3-OXAZOL-2-AMINE;BUTTPARK 93\04-04;2-Amino-4-methyloxazole, tech;2-Amino-4-methyloxazol;4-Methyl-1,3-oxazol-2-amine, tech;2-AMINO-4-METHYLOXAZOL: TECH.;4-METHYL-OXAZOL-2-YLAMINE
• CAS NO: 35629-70-0
• Molecular Formula: C₄H₆N₂O
• Molecular Weight: 98.1
• Product Categories: Amines;Oxazoles, Isoxazoles & Benzoxazoles;Oxazoles, Isoxazoles & Benzoxazoles
• Mol File: 35629-70-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 67-69°C 0,5mm
• Flash Point: 76.717 °C
• Appearance: /
• Density: 1.1890 (rough estimate)
• Vapor Pressure: 0.28mmHg at 25°C
• Refractive Index: 1.4327 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.80±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-4-METHYLOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-METHYLOXAZOLE(35629-70-0)
• EPA Substance Registry System: 2-AMINO-4-METHYLOXAZOLE(35629-70-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-24/25-22
• HazardClass: IRRITANT
• Hazardous Substances Data: 35629-70-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to yellow solid

Synthesis Reference(s)

Journal of Medicinal Chemistry, 14, p. 1075, 1971 DOI: 10.1021/jm00293a014

InChI:InChI=1/C4H6N2O/c1-3-2-7-4(5)6-3/h2H,1H3,(H2,5,6)

Upstream product

• 57-13-6 urea 
• 598-31-2 1-bromoacetone 
• 420-04-2 CYANAMID 
• 116-09-6 hydroxy-2-propanone 

Downstream Products

• 32093-97-3 N-methyl-N'-(4-methyloxazol-2-yl)thiourea 
• 55243-97-5 2-amino-N,4-dimethyloxazole-5-carbothioamide 
• 221089-40-3 1-(4-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea 
• 221089-27-6 1-(5-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea 
• 221089-41-4 1-(2-Chloro-6-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea 
• 226711-07-5 (4-methyl-oxazol-2-yl)-carbamic acid benzyl ester 
• 191019-22-4 2-imino-4-methyl-3-(4'-chlorophenacyl)-2,3-dihydrooxazole 

Relevant articles and documents

Synthesis of 17beta-(2-amino-oxazol-4-yl)-steroids.

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Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: Selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

The design, synthesis, and biological evaluation of arylsulfonamidooxazoles as 11β-HSD1 inhibitors and the serendipitous discovery of β-keto sulfones as potent 11β-HSD1 inhibitors are described here. These two classes of compounds are not active against 11β-HSD2 and therefore may have significant therapeutic potential for metabolic syndrome, type 2 diabetes and related metabolic dysfunctions.

Antianaphylactic agents. 1. 2-(Acylamino)oxazoles

The synthesis and biological properties of 35 2-(acylamino)oxazoles are described. The majority of the compounds inhibit the release of slow-reacting substance of anaphylaxis (SRS-A) in vitro from sensitized guinea pig chopped lung. In addition, several of the compounds inhibited the release of SRS-A from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.