35644-76-9Relevant academic research and scientific papers
Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors
Ohtawa, Masaki,Arima, Shiho,Ichida, Naoki,Terayama, Tomiaki,Ohno, Hironao,Yamazaki, Takaya,Ohshiro, Taichi,Sato, Noriko,Omura, Satoshi,Tomoda, Hiroshi,Nagamitsu, Tohru
, p. 411 - 421 (2018)
Currently, pyripyropene A, which is isolated from the culture broth of Aspergillus fumigatus FO-1289, is the only compound known to strongly and selectively inhibit the isozyme sterol O-acyltransferase 2 (SOAT2). To aid in the development of new cholester
NOVEL PHARMACEUTICAL COMPOUND HAVING INHIBITORY ACTIVITY AGAINST CHOLESTEROL ACYLTRANSFERASE ISOZYME 2 (ACAT 2)
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Paragraph 0136-0137, (2016/10/08)
PROBLEM TO BE SOLVED: To provide a compound having an action mechanism different from a statin-based medicine and an inhibitory activity against cholesterol acyltransferase isozyme 2 (ACAT 2), and a pharmaceutical composition comprising the compound. SOLU
