356518-15-5

Basic information

• Product Name: 2-Propenoic acid, 2-methyl-3-(2-methylphenyl)-, methyl ester, (2E)-
• CAS NO: 356518-15-5
• Molecular Formula: C12H14O2
• Molecular Weight: 190.242
• Mol File: 356518-15-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-methyl-3-(2-methylphenyl)-, methyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-methyl-3-(2-methylphenyl)-, methyl ester, (2E)-(356518-15-5)
• EPA Substance Registry System: 2-Propenoic acid, 2-methyl-3-(2-methylphenyl)-, methyl ester, (2E)-(356518-15-5)

Safety Data

• Hazardous Substances Data: 356518-15-5(Hazardous Substances Data)

Upstream product

• 529-20-4 2-methylphenyl aldehyde 
• 2605-68-7 methyl 2-(triphenylphosphoranylidene)propionate 
• 95-46-5 2-methylphenyl bromide 
• 80-62-6 methacrylic acid methyl ester 
• 95-49-8 2-methylchlorobenzene 

Downstream Products

• 509095-77-6 C₁₁H₁₂⁽²⁾H₂O 
• 509095-84-5 C₁₁H₁₁⁽²⁾H₂Cl 
• 509095-91-4 C₁₁H₁₁⁽²⁾H₃ 

Relevant articles and documents

A versatile catalyst for heck reactions of aryl chlorides and aryl bromides under mild conditions

In the presence of Cy2NMe, Pd/P(t-Bu)3 serves as an exceptionally mild and versatile catalyst for Heck reactions of aryl chlorides and bromides. A sterically and electronically diverse array of aryl bromides, as well as activated aryl chlorides, couple with a range of mono- and disubstituted olefins at room temperature, furnishing the arylated product with high E/Z stereoselection. The corresponding reactions of a broad spectrum of electron-neutral and electron-rich aryl chlorides proceed at elevated temperature, also with high selectivity. In terms of scope and mildness, Pd/P(t-Bu)3/Cy2NMe represents an advance over previously reported catalysts for these Heck coupling processes.