35652-37-0

Upstream product

• 1165952-92-0 cyclohexa-1,4-diene 
• 406682-04-0 cis-cyclohex-4-ene-1,2-diol 
• 285-52-9 1,4-cyclohexadiene diepoxide 
• 97949-68-3 (1S,3R,4S,6R)-7-Oxa-bicyclo[4.1.0]heptane-3,4-diol 
• 6261-00-3 (+/-)-1r,2t,4c,5t-tetrakis-benzoyloxy-cyclohexane 

Downstream Products

• 6261-00-3 (+/-)-1r,2t,4c,5t-tetrakis-benzoyloxy-cyclohexane 
• 6261-46-7 (+/-)-1r,2t,4c,5t-tetraacetoxy-cyclohexane 
• 623549-32-6 anti-1,2,4,5-tetracetoxycyclohexane 
• 143615-77-4 cyclohexane-r-1,c-2,t-4,t-5-tetrayl tetraactetate 
• 120-12-7 anthracene 

Relevant academic research and scientific papers

Benzannulation via ruthenium-catalyzed diol-diene [4+2] cycloaddition: One- and two-directional syntheses of fluoranthenes and acenes

A new benzannulation protocol is described and applied to the synthesis of polycyclic aromatic hydrocarbons. Ruthenium(0)-catalyzed diol-diene [4+2] cycloaddition delivers cyclohex-1-ene-4,5-diols, which are subject to aromatization upon dehydration or Nicholas diol deoxydehydration. Employing diol and tetraol reactants, benzannulation can be conducted efficiently in one- and two-directional modes, respectively, as illustrated in the construction of substituted fluoranthenes and acenes.

NOVEL PROCESS FOR PRODUCING 1,2-DIOL

A process for producing a 1,2-diol through the reaction of an olefin with hydrogen peroxide. The process is highly efficient and highly selective and catalyst recovery and reuse are easy. It does not use any strong acid or strong base causative of apparatus corrosion. The process for producing a 1,2-diol is characterized by reacting an olefin with hydrogen peroxide in the presence of a polymer having a sulfo group.

Catalytic Dihydroxylation of Olefins with Hydrogen Peroxide: An Organic-Solvent- and Metal-Free System

Green and convenient: Olefins are oxidized to 1,2-diols in high yield with 30% H2O2 in the presence of resin-supported sulfonic acid (see scheme) under metal-free conditions without any organic solvent. The catalyst can be recycled easily and is effective for at least 10 cycles.

Scope of the directed dihydroxylation: Application to cyclic homoallylic alcohols and trihaloacetamides

The synthesis and directed dihydroxylation of a range of cyclic alkenes was investigated. Both homoallylic alcohols and homoallylic trihaloacetamides were found to be efficient directing groups, giving rise to good to excellent levels of remote asymmetric induction with OsO4-TMEDA. Interestingly, in all cases examined, trifluoroacetamides were found to be superior to trichloroacetamides as directing groups and an argument is presented which rationalises this observation.

DERMATOLOGICAL COMPOSITIONS AND METHODS

Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.

On the stereoselectivity in bisdihydroxylation of 1,5-cyclooctadiene with osmium tetroxide

In the bisdihydroxylation of 1,5-cyclooctadiene with OsO4, use of a stoichiometric amount of OsO4 yielded a 1:1 mixture of syn- and anti-isomers, while use of a catalytic amount of OsO4 gave only syn-(1R*,2S*,5R*,6S*)-cyclooctane-1,2,5,6-tetrol. This syn-selectivity was attributed to the favorable formation of an intramolecular osmium(VI) bisglycolate ester in the catalytic reaction.

Treatment of neurodegenerative diseases

Disclosed are methods for increasing the differentiation of mammalian neuronal cells for purposes of treating neurodegenerative diseases or nerve damage by administration of various compounds including alcohols, diols and/or triols and their analogues.

Treatment of diseases mediated by the nitric oxide/cGMP/protein kinase G pathway

Disclosed are methods and compositions for stimulating cellular nitric oxide (NO) synthesis, cyclic guanosine monophosphate levels (cGMP), and protein kinase G (PKG) activity for purposes of treating diseases mediated by deficiencies in the NO/cGMP/PKG signal transduction pathway, by administration of various compounds including alcohols, diols and/or triols and their analogues.

One-pot synthesis from 1,4-cyclohexadiene of (±)-1,4/2,5-cyclohexanetetrol, a naturally occurring cyclitol derivative

SeO2-catalyzed direct hydroxylation of 1,4-cyclohexadiene with two molar equivalents of 30% H2O2 afforded (±)-1,4/2,5-cyclohexanetetrol, a naturally occurring cyclitol derivative, as the sole product in a good yield (88%).