35653-54-4

Usage

Uses

Used in Pharmaceutical Research:
1-Benzyl-3-phenethyl-2-thiourea is used as a research compound for studying the role of arylalkylamine N-acetyltransferase in the biosynthesis of melatonin. Its inhibitory properties make it a valuable tool in understanding the enzyme's function and potential therapeutic targets related to melatonin production.
Used in Drug Development:
1-Benzyl-3-phenethyl-2-thiourea is used as a lead compound in the development of new drugs targeting arylalkylamine N-acetyltransferase. Its potent inhibitory activity may contribute to the creation of novel therapeutic agents for conditions related to melatonin dysregulation.
Used in Toxicological Studies:
1-Benzyl-3-phenethyl-2-thiourea is used in toxicological research to investigate its potential toxic effects and to understand the mechanisms of its toxicity. This information is crucial for assessing the safety of the compound and for developing strategies to mitigate its harmful effects.
Used in Safety and Handling Protocols:
1-Benzyl-3-phenethyl-2-thiourea is used as a reference compound in the development of safety and handling protocols for chemical compounds with similar properties. Its known toxicity serves as a reminder of the importance of proper protective measures and adherence to safety procedures when working with potentially harmful chemicals.

InChI:InChI=1/C16H18N2S/c19-16(18-13-15-9-5-2-6-10-15)17-12-11-14-7-3-1-4-8-14/h1-10H,11-13H2,(H2,17,18,19)

Upstream product

• 2257-09-2 Phenethyl isothiocyanate 
• 100-46-9 benzylamine 
• 88333-03-3 Benzyl isocyanide 
• 64-04-0 phenethylamine 
• 59795-89-0 phenethyl isocyanide 
• 622-78-6 Benzyl isothiocyanate 

Relevant academic research and scientific papers

Gram Scalable Method to Synthesize Biscarbodiimides and Asymmetric Monocarbodiimides: A Platform to Access an Array of Phosphaguanidines, Amidines, and Guanidines

A mild, broadly functional group tolerant methodology has been developed to access a variety of mono- and bis-carbodiimides in good yield and high purity on multigram scale. Direct addition into these versatile motifs facilitated the rapid synthesis of a library of novel amidinines, guanidines, and phosphaguandines.

Continuous-flow synthesis of thioureas, enabled by aqueous polysulfide solution

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

Pos [...] 4 group metal olefin polymerization catalyst

Embodiments are directed to phosphaguanidine metal complexes of formula I and using those complexes in α-olefin polymerization systems.

Three-component reaction between isocyanides, aliphatic amines and elemental sulfur: Preparation of thioureas under mild conditions with complete atom economy

The reaction of isocyanides with aliphatic amines in the presence of elemental sulfur was found to proceed efficiently at, or near, room temperature to produce thioureas in excellent yields and with complete atom economy.

Synthesis and biological evaluation of new 2,3-dihydrothiazole derivatives for antimicrobial, antihypertensive, and anticonvulsant activities

A novel series of 2-arylimino-2,3-dihydrothiazole derivatives, substituted in the 3-position with a β-phenethyl moiety and the 4-position with substituted aryl functions, was synthesized as potential antimicrobial, antihypertensive and anticonvulsive agen