356531-41-4Relevant academic research and scientific papers
A Short Approach to N -Aryl-1,2,3,4-tetrahydroisoquinolines from N -(2-Bromobenzyl)anilines via a Reductive Amination/Palladium-Catalyzed Ethoxyvinylation/Reductive N -Alkylation Sequence
Glas, Carina,Wirawan, Ricky,Bracher, Franz
, p. 1943 - 1954 (2021/01/18)
N -Aryl-1,2,3,4-tetrahydroisoquinolines are obtained via a convenient and short protocol with a broad range of substituents on both aromatic rings and high functional group tolerance. Starting from readily available ortho -brominated aromatic aldehydes and primary aromatic amines, condensation of these building blocks under reductive conditions gives N -aryl 2-bromobenzylamines. The C-3/C-4-unit of the tetrahydroisoquinoline is introduced using commercially available 2-ethoxyvinyl pinacolboronate under Suzuki conditions. Finally, the obtained crude ortho -ethoxyvinyl benzylamines are cyclized via an intramolecular reductive amination using the combination of triethylsilane/TFA to give the desired N -aryl-1,2,3,4-tetrahydroisoquinolines.
Importance of open structure of nonmetal based catalyst in hydrogen bond promoted methanolysis of activated amide: Structure dynamics between monomer and dimer enabling recombinant covalent, dative, and hydrogen bonds
Oishi, Shunsuke,Yoshimoto, Junichi,Saito, Susumu
supporting information; experimental part, p. 8748 - 8749 (2009/12/04)
(Figure Presented) We disclosed structural dynamics hidden behind a series of aminoorganoboron (AOB) compounds that involved a recombinant of covalent, dative, and hydrogen bonds. A combination process occurred via reorganizing elements and bonds between
