356543-07-2

Upstream product

• 99-91-2 para-chloroacetophenone 
• 93-02-7 2,5-dimethoxybenzaldehyde 

Downstream Products

• 1346457-97-3 1-(4-aminosulfonylphenyl)-3-(4-chlorophenyl)-5-(2,5-dimethoxyphenyl)pyrazoline 
• 1003584-71-1 4-[3-(4-chlorophenyl)-5-(2,5-dimethoxyphenyl)pyrazol-1-yl]benzenesulfonamide 
• 1003584-68-6 3-(4-chlorophenyl)-5-(2,5-dimethoxyphenyl)-1-phenylpyrazole 
• 767349-33-7 3-(2,5-dihydroxyphenyl)-1-(4-chlorophenyl)propenone 
• 1003584-74-4 N-acetyl-4-[3-(4-chlorophenyl)-5-(2,5-dimethoxyphenyl)pyrazol-1-yl]benzenesulfonamide 

Relevant academic research and scientific papers

Synthesis of 1-(4-aminosulfonylphenyl)-3,5-diarylpyrazoline derivatives as potent antiinflammatory and antimicrobial agents

A new series of 1-(4-aminosulfonylphenyl)-3, 5-diaryl pyrazolines (5) was synthesized by the reaction of appropriate chalcones 3 with 4- hydrazinobenzenesulfonamide hydrochloride (4) in ethanol in the presence of catalytic amount of acetic acid. All newly

Design, synthesis, and in vitro evaluation of cytotoxic activity of new substituted 1,4-benzoquinones and hydroquinones

A new series of p-benzoquinones, hydroquinones, and quinol dimethyl ethers substituted by a pyrazole ring either directly or after an oxoethyl linker was synthesized and screened for in vitro cytotoxic activity. Compounds 8d, f, g, i, and 9c, f, and 13c exhibited broad-spectrum activity (GI50 MG-MID values 9.27-14.72 μM). With regard to sensitivity, compounds 8f and 9c, f have proved to possess a remarkable activity against leukemia tumor cell lines (GI50 = 3.43-5.03 μM). Indeed, compound 13c showed the highest activity profile against individual leukemia subpanel cell line SR (GI 50 = 0.91 μM).