356546-36-6Relevant academic research and scientific papers
A novel [2 + 2] photodimerization of N-[(E)-3,4-methylenedioxycinnamoyl]dopamine in the solid state.
Ito,Horie,Shindo
, p. 2411 - 2413 (2001)
[reaction: see text] To give photoreactivity to catecholamines, N-cinnamoyl-substituted dopamines (E)-5a-5c and O,O'-dimethyldopamines (E)-3a-3c were prepared under solvent-free conditions. A particularly interesting observed photoreactivity was that of N-[(E)-3,4-methylenedioxycinnamoyl]dopamine ((E)-5c), which underwent a novel type of [2 + 2] photodimerization in the solid state, giving exclusively a tricyclic product 8. This reaction is the first example of solid-state photoaddition of an alkene to the benzene ring.
Synthesis and antihyperglycemic activity of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines
Dwivedi, Atma P.,Kumar, Shailesh,Varshney, Vandana,Singh, Amar B.,Srivastava, Arvind K.,Sahu, Devi P.
, p. 2301 - 2305 (2008/09/21)
A series of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines were synthesized and evaluated for their antihyperglycemic activity. Compounds 3g and 6d exhibited lowering of postprandial plasma glucose by 30.7%, 23.3% in SLM and 25.6%, 25.4% in STZ models respectively which is significant compared to metformin and glybenclamide. Other compounds exhibited moderate to good activity ranging from 19.5% to 32.8% in SLM and 3.26% to 25.4% in STZ models.
