356548-44-2

Upstream product

• 356548-59-9 tert-Butyl-[(E)-(1S,3S)-7-(4-methoxy-benzyloxy)-1-((R)-1-methyl-but-3-enyl)-3-methylsulfanylmethoxy-hept-5-enyloxy]-dimethyl-silane 
• 356548-50-0 (5S,7S,8R)-7-(tert-Butyl-dimethyl-silanyloxy)-8-methyl-5-methylsulfanylmethoxy-undec-10-en-2-ynoic acid methyl ester 
• 356548-47-5 (3R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-3-methyl-pentan-1-ol 
• 356548-48-6 tert-Butyl-[(1S,2R)-1-((R)-2,2-diethyl-[1,3]dioxolan-4-ylmethyl)-2-methyl-pent-4-enyloxy]-dimethyl-silane 
• 356548-56-6 (2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-methyl-oct-7-ene-1,2-diol 
• 356548-49-7 tert-Butyl-dimethyl-((1S,2R)-2-methyl-1-(R)-1-oxiranylmethyl-pent-4-enyloxy)-silane 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 356548-58-8 (E)-(5S,7S,8R)-7-(tert-Butyl-dimethyl-silanyloxy)-8-methyl-5-methylsulfanylmethoxy-undeca-2,10-dien-1-ol 
• 356548-57-7 (5S,7S,8R)-7-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-8-methyl-undec-10-en-2-ynoic acid methyl ester 
• 356548-55-5 (3R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-((R)-2,2-diethyl-[1,3]dioxolan-4-yl)-3-methyl-pentanal 

Downstream Products

• 356548-43-1 2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-4-(4-methoxy-benzyloxy)-but-2-enyl]-4-methyl-hept-6-enyl ester 

Relevant academic research and scientific papers

A first generation total synthesis of (+)-salicylihalamide A

An efficient total synthesis of (+)-salicylihalamide (1) is described. The synthetic strategy features a highly E-selective ring-closing metathesis to construct the 12-membered salicylihalamide A macrocycle and a practical method for installation of the labile ene-hepta-(Z,Z)-dienamide side chain, which relies on a Curtius rearrangement to forge the C18-N bond with subsequent N-acylation.