356578-47-7

Basic information

• Product Name: 4-(4-bromophenyl)-1-[(2-chlorophenyl)carbonyl]thiosemicarbazide
• CAS NO: 356578-47-7
• Molecular Weight: 384.684
• Mol File: 356578-47-7.mol

Chemical Properties

• CAS DataBase Reference: 4-(4-bromophenyl)-1-[(2-chlorophenyl)carbonyl]thiosemicarbazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromophenyl)-1-[(2-chlorophenyl)carbonyl]thiosemicarbazide(356578-47-7)
• EPA Substance Registry System: 4-(4-bromophenyl)-1-[(2-chlorophenyl)carbonyl]thiosemicarbazide(356578-47-7)

Safety Data

• Hazardous Substances Data: 356578-47-7(Hazardous Substances Data)

Upstream product

• 1985-12-2 4-Bromophenyl isothiocyanate 
• 5814-05-1 2-chlorobenzoylhydrazide 

Downstream Products

• 1403137-37-0 4-(4-bromophenyl)-5-(2-chlorophenyl)-2-(morpholin-4-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 1403137-34-7 4-(4-bromophenyl)-5-(2-chlorophenyl)-2-(piperidin-1-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 1403137-31-4 4-(4-bromophenyl)-5-(2-chlorophenyl)-2-(pyrrolidin-1-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 1403137-28-9 4-(4-bromophenyl)-5-(2-chlorophenyl)-2-[(diethylamino)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 1403137-14-3 4-(4-bromophenyl)-5-(2-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 

Relevant articles and documents

Microbiologically active Mannich bases derived from 1,2,4-triazoles. the effect of C-5 substituent on antibacterial activity

Our research proved that chemical character of the C-5 substituent significantly determines the antibacterial activity of the Mannich bases derived from 4,5-disubstituted 1,2,4-triazole-3-thiones. This activity was considerably increased by an introduction of a chlorine atom to the phenyl ring. The obtained compounds were particularly active against opportunistic bacteria (Bacillus subtilis and Bacillus cereus). The antibacterial activity of some Mannich bases was similar or higher than the activity of commonly used antibiotics such as ampicillin and cefuroxime.