35659-94-0Relevant academic research and scientific papers
Alkylation of 1,3-benzothiazin-4-one 2-oxo-, 2-arylimino-, and 2-thioxo derivatives
Shestakov, Alexandr S.,Prezent, Mikhail A.,Zlatoustovskaya, Evgenia O.,Shikhaliev, Khidmet S.,Falaleev, Alexandr V.,Sidorenko, Oleg E.
, p. 370 - 376 (2016/01/12)
[Figure not available: see fulltext.] Sodium salt of 3H -benzo[e][1,3]thiazine-2,4-dione is easily alkylated at position 3. In the case of 2-(arylimino)-2,3-dihydrobenzo[e][1,3]-thiazin-4-ones, the alkylation reaction at this position occurs regioselectively. Alkylation of 2-thioxo-2,3-dihydrobenzo[e][1,3]thiazin-4-one under the same conditions produced regioisomers, but S-alkylation at the exocyclic sulfur atom occurred in the presence of triethylamine. The reaction of 1-(4-oxo-3,4-dihydrobenzo[e][1,3]thiazin-2-ylidene)guanidine with methyl anthranilate led to the formation of tetracyclic quinazolino[2,1-b]quinazolinedione.
