35669-34-2

Usage

Uses

Used in Metabolic Studies:
D-[6,6'-2H2]GALACTOSE is used as a tracer for metabolic studies to trace the metabolism of galactose in biological systems. Its labeled form allows for the tracking and quantification of galactose uptake, utilization, and conversion in various metabolic pathways, making it a valuable tool in research related to galactose metabolism and related disorders such as galactosemia.
Used in Analytical Method Development:
D-[6,6'-2H2]GALACTOSE is used in the development and testing of new analytical methods for galactose detection and quantification in biological samples. Its stable isotope labeling provides a reliable and accurate means for measuring galactose levels, which can be crucial for understanding metabolic processes and diagnosing related conditions.

Upstream product

• 79774-22-4 1,2:5,6-di-O-isopropylidene-α-D-(6,6'-²H₂)-glucofuranose 
• 68006-60-0 1,2-O-Isopropyliden-α-D-<6,6-D2>glucofuranose 
• 20513-98-8 1,2-O-isopropylidene-α-D-glucofuranurono-6,3-lactone 
• 4709-04-0 1,2-O-isopropylidene-α-D-5,6,6'-(²H₃)-glucofuranose 
• 79774-23-5 1,2:5,6-di-O-isopropylidene-α-D-(5,6,6'-²H₃)-glucofuranose 

Relevant academic research and scientific papers

Biosynthesis of Natural Products with a P-C Bond, I. - Incorporation of D-Glucose into (2-Aminoethyl)phosphonic Acid in Tetrahymena thermophila

The phosphate-phosphonate rearrangement is tested as a model reaction for the biosynthesis of the P-C bond as alternative to the rearrangement of phosphoenolpyruvate.D-glucose was prepared and added to the growth medium of Tetrahymena thermophila. (2-Aminoethyl)phosphonic acid (AEP) (1) was isolated from the wet cell mass by hydrolysis with 6N HCl and ion exchange chromatography and was derivatized to the crystalline 4-bromobenzamide 26.The amount of -AEP in admixture with unlabeled AEP was up to 43percent, which is not in agreement with an enzymic phosphate-phosphonate rearrangement of dihydroxyacetone phosphate, for which monodeutereated AEP would be expected.For comparison -AEP (31) was prepared starting from 2-amino-ethanol.

NUCLEAR MAGNETIC RESONANCE STUDIES OF D-ERYTHROSE 4-PHOSPHATE IN AQUEOUS SOLUTION. STRUCTURES OF THE MAJOR CONTRIBUTING MONOMERIC AND DIMERIC FORMS

N.m.r. studies show that a concentrated (ca. 1.0 M ) aqueous solution of D-erythrose 4-phosphate is composed of an equilibrium mixture of the monomeric aldehyde and hydrated aldehyde forms, which interconvert rapidly, together with a major contribution from three dimeric forms.In dilute solutions (ca. 0.04 M ), the hydrated monomer is predominant and dimeric forms are not detectable at this concentration.The chemical structures and stereochemistry of the three dimers have been elucidated by (1)H- and (13)C n.m.r. spectroscopy of D-erythrose 4-phosphate and its (4,4-2H2) and (3,4,4'-2H3) derivatives, aided by the use of the model compounds, glycolaldehyde, D-glyceraldehyde, and DL-glyceraldehyde 3-phosphate, which also form dimers in concenrated aqueous solution.In some cases, the tert-butyldimethylsilyl derivatives of the model dimeric compounds were prepared and isolated.The two major dimers of D-erythrose 4-phosphate, I and II are asymmetrically substituted 1,3-dioxane and 1,3-dioxolane stuctures, respectively, and dimer III is the α anomer of dimer I.