3567-00-8 Usage
Uses
Rubrofusarin is useful for treating chronic restraint stress-induced depressive symptoms.
Definition
ChEBI: A member of the class of benzochromenones that is benzo[g]chromen-4-one carrying two additional hydroxy substituents at positions 5 and 6 as well as methyl and methoxy substituents at positions 2 and 8 respectively. An orange polyketide pigmen
that is a common intermediate in many different fungal biosynthetic pathways.
Biochem/physiol Actions
Rubrofusarin is an orange polyketide pigment produced by Fusarium graminearum and other fungal species that exhibit potent anti-cancer and anti-mycobacterial activities. Rubrofusarin is a mycotoxin that inhibits human DNA topoisomerase II-α.. Additionally, Rubrofusarin shows a significant anti-estrogenic activity.
Check Digit Verification of cas no
The CAS Registry Mumber 3567-00-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,6 and 7 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3567-00:
(6*3)+(5*5)+(4*6)+(3*7)+(2*0)+(1*0)=88
88 % 10 = 8
So 3567-00-8 is a valid CAS Registry Number.
InChI:InChI=1/C15H12O5/c1-7-3-10(16)14-12(20-7)5-8-4-9(19-2)6-11(17)13(8)15(14)18/h3-6,17-18H,1-2H3
3567-00-8Relevant articles and documents
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Baker,P.M.,Roberts,J.C.
, p. 2234 - 2237 (1966)
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Biomimetic Syntheses of the Polyketide Fungal Metabolites Alternariol and Rubrofusarin: Models for Cyclisation Reactions Catalysed by Polyketide Synthase Enzymes
Abell, Chris,Bush, Brian D.,Staunton, James
, p. 15 - 17 (2007/10/02)
Various phenolic polyketone derivatives containing thioester groups, closely analogous in structure to proposed thioester intermediates bound to polyketide synthase enzymes, undergo highly regioselective biomimetic cyclisations to form one or the other of the heptaketide metabolites, rubrofusarin and alternariol methyl ether.
