356788-94-8

Basic information

• Product Name: 2-Butenoicacid,4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-,(2Z)-(9CI)
• Synonyms: 2-Butenoicacid,4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-,(2Z)-(9CI)
• CAS NO: 356788-94-8
• Molecular Formula: C10H17NO4
• Molecular Weight: 215.25
• Product Categories: N-BOC
• Mol File: 356788-94-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Butenoicacid,4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-,(2Z)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoicacid,4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-,(2Z)-(9CI)(356788-94-8)
• EPA Substance Registry System: 2-Butenoicacid,4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-,(2Z)-(9CI)(356788-94-8)

Safety Data

• Hazardous Substances Data: 356788-94-8(Hazardous Substances Data)

Upstream product

• 30094-28-1 2-(diethylphosphono)propionic acid 
• 89711-08-0 N-(t-butoxycarbonyl)glycinal 
• 3699-66-9 ethyl 2-diethoxyphosphorylpropionate 
• 121505-93-9 tert-butyl N-{[methoxy(methyl)carbamoyl]methyl}carbamate 
• 356788-86-8 ethyl (cis)-4-[(t-butoxycarbonyl)amino]-2-methyl-2-butenoate 

Relevant articles and documents

Structural investigation of "cis" and "trans" vinylogous peptides: cis-vinylog turn in folded cis-vinylogous peptides, an excellent mimic of the natural β-turn

Various sequences of modified peptides including those containing a cis- or trans-vinylogous residue have been studied using X-ray diffraction in the solid state and 1H NMR and IR spectroscopy in solution. A cis-vinylogous residue promotes an NH to CO intramolecular H-bond, closing a nine-membered pseudocycle that stabilizes a folded moiety that we proposed to name the cis-vinylogous turn. A trans-vinylogous residue involves an extended conformation. Two consecutive vinylogous residues retain their own structural propensity: "Xaatr"-"Xaacis" or "Xaacis"-"Xaatr" sequence is singly folded, whereas "Xaacis"-"Xaacis" sequence is doubly folded. Oligo vinylogs with all-trans or all-cis or alternating cis-trans motifs could constitute new classes of foldamers.