35684-61-8Relevant academic research and scientific papers
Substituted Macrocyclic Compounds and Related Methods of Treatment
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Paragraph 0423; 0426, (2021/05/28)
The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.
Stereodivergent Synthesis of 3-Hydroxyprolines and 3-Hydroxypipecolic Acids via Ketoreductase-Catalyzed Dynamic Kinetic Reduction
Prier, Christopher K.,Lo, Michael M.-C.,Li, Hongming,Yasuda, Nobuyoshi
supporting information, p. 5140 - 5143 (2019/11/03)
We report a practical enzymatic approach for the stereoselective synthesis of hydroxylated cyclic amino acids. Using ketoreductases, cyclic ketoesters are converted with high diastereo- and enantioselectivity to all isomers of 3-hydroxyproline and 3-hydroxypipecolic acid via a dynamic kinetic reduction reaction. This work highlights the ability of enzymes to provide solutions to challenges in stereoselective synthesis. (Figure presented.).
