3569-20-8

Usage

Uses

Used in Pharmaceutical Research:
3-(1H-INDOL-3-YL)-BUTYRIC ACID is used as a research compound for studying neurotransmitters and psychopharmacology. Its potential anti-cancer and immune-modulating properties make it a promising candidate for the development of new drugs.
Used in Neurological and Psychiatric Disorders:
3-(1H-INDOL-3-YL)-BUTYRIC ACID is being investigated as a potential treatment for various neurological and psychiatric disorders due to its potential mood and behavior regulating properties.
Used in Drug Development:
3-(1H-INDOL-3-YL)-BUTYRIC ACID's unique structure and biological activity make it an important molecule in the field of medicinal chemistry and drug development, with potential applications in the creation of new therapeutic agents.

InChI:InChI=1/C12H13NO2/c1-8(6-12(14)15)10-7-13-11-5-3-2-4-9(10)11/h2-5,7-8,13H,6H2,1H3,(H,14,15)

Upstream product

• 67996-15-0 ethyl ester of 3-(3-indolyl)butyric acid 
• 120-72-9 indole 
• 26583-97-1 (2E-but-2-enoyl)-phosphonic acid dimethyl ester 
• 114495-29-3 ethyl<(3-acetyl-4-indolyl)thio>acetate 
• 72527-77-6 3-acetyl-4-iodoindole 
• 81038-38-2 4-iodo-1H-indole 
• 478916-44-8 2-carboxyl-3-methyl-3,5-dihydro-2H-thiopyrano[4,3,2-cd]indole 
• 114515-68-3 ethyl 3-methyl-5H-thiopyrano[4,3,2-cd]indole-2-carboxylate 
• 513-35-9 2-methyl-but-2-ene 
• 881035-05-8 3-(1H-Indol-3-yl)-butanal 
• 74639-52-4 (S)-3-(1H-indol-3-yl)-butyric acid methyl ester 
• 67996-05-8 5-<1-(1H-indol-3-yl)ethyl>-2,2-dimethyl-1,3-dioxane-4,6-dione 

Relevant academic research and scientific papers

Indole derivatives and its preparation method

The invention relates to a novel antibacterial compound, i.e. an indole derivative, a three-dimensional isomerism or medical salt, solvent compound or aquo-complex as well as a preparation method, a medicine composition containing the compound and an application of the compound in preparing an antibiotic drug.

CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

DERIVATIVES OF AZA ADAMANTANE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

DERIVATIVES OF AZA ADAMANTANE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

Enantioselective Friedel-Crafts alkylation reaction of indoles with α,β-unsaturated acyl phosphonates catalyzed by chiral phosphoric acid

A variety of indoles underwent enantioselective Friedel-Crafts alkylation with α,β-unsaturated acyl phosphonates in the presence of 10 mol% chiral BINOL-based phosphoric acid and subsequent treatment with methanol and DBU to give methyl 3-(indol-3-yl)prop

Enantioselective transformation of alpha, beta-unsaturated aldehydes using chiral organic catalysts

Nonmetallic organic catalysts are provided that facilitate the enantioselective reaction of α,β-unsaturated aldehydes. The catalysts are chiral imidazolidinone compounds having the structure of formula (IIA) or (IIB) or are acid addition salts thereof, wherein, in one preferred embodiment, R1 is C1-C6 alkyl, R2 is tri(C1-C6 alkyl)-substituted methyl, R3 and R4 are hydrogen, and R5 is phenyl optionally substituted with 1 or 2 substituents selected from the group consisting of halo, hydroxyl, and C1-C6 alkyl. The chiral imidazolidinones are useful in catalyzing a wide variety of reactions, including cycloaddition reactions, Friedel-Crafts alkylation reactions, and Michael additions.

Growth inhibitors against algae and moss

Growth inhibitors containing 3-(3-indolyl) butyric acid shown by and its salts can prevent the growth of algae and moss without harming the plants being cultivated or the worker or adversely affecting the environment.

Growth inhibitors against algae and moss

Growth inhibitors containing 3-(3-indolyl) butyric acid shown by and its salts can prevent the growth of algae and moss without harming the plants being cultivated or the worker or adversely affecting the environment.

Hexahydropyrroloindoles - Attempts to Synthesize 2-Indolyl Thioethers

The N-tryptamine derivatives 9, 11, 12, and 19 with the functional groups CN, CONH2, CO2H, and CO2Me, respectively, in the α position to the indole ring have been synthesized.Sensitized photooxiation of 9, 12, 19, N-Boc--tryptophan (21), and N-Boc-tryptamine (22) affords the hexahydropyrroloindoles 23-27, in the case of 11 the ring closure occurs at the amine nitrogen to give the ketone 28, N-Boc-homotryptamine (31) yields the hexahydropyridoindole 32, whereas no azetidine formation from 2-(3-indolyl)glycine (36) is observed.The oxi mes 34a and 34 b, intermediates in the synthesis of 36, have been separated chromatographically and characterized NMR spectroscopically as E and Z-isomers, respectively.- Attempts to introduce with cysteine derivatives a thioether group in position 2 of the compounds described above, failed. 21, 22, 26, 27, and N-Boc-2-(3-indolyl)propylamine (43), bearing a methyl group in the α position to the indole ring, and its photooxidation product 44 show only thin-layer chromatographically detectable thioether formation.