35697-16-6

Basic information

• Product Name: cis-5,6,7,8-tetrahydronaphthalene-1,6,7-triol
• Synonyms: cis-5,6,7,8-tetrahydronaphthalene-1,6,7-triol;cis-5,6,7,8-Tetrahydro-1,6,7-naphthalenetriol;cis-5,6,7,8-Tetrahydrogen-6,7-Dihydroxy-1-Naphthol
• CAS NO: 35697-16-6
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.20048
• EINECS: 252-682-6
• Mol File: 35697-16-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 188-188.5 °C(Solv: ethanol (64-17-5))
• Boiling Point: 363.8 °C at 760 mmHg
• Flash Point: 183.4 °C
• Appearance: /
• Density: 1.4 g/cm³
• Vapor Pressure: 6.25E-06mmHg at 25°C
• Refractive Index: 1.67
• PKA: 10.29±0.60(Predicted)
• CAS DataBase Reference: cis-5,6,7,8-tetrahydronaphthalene-1,6,7-triol(CAS DataBase Reference)
• NIST Chemistry Reference: cis-5,6,7,8-tetrahydronaphthalene-1,6,7-triol(35697-16-6)
• EPA Substance Registry System: cis-5,6,7,8-tetrahydronaphthalene-1,6,7-triol(35697-16-6)

Safety Data

• Hazardous Substances Data: 35697-16-6(Hazardous Substances Data)

Usage

Uses

cis-5,6,7,8-Tetrahydro-1,6,7-naphthalenetriol is an intermediate used to prepare nondepressant β-adrenergic blocking agents.

InChI:InChI=1/C10H12O3/c11-8-3-1-2-6-4-9(12)10(13)5-7(6)8/h1-3,9-13H,4-5H2

Upstream product

• 52187-19-6 3a-9a-cis-3a,4,9,9a-tetrahydro-2,2-dimethyl-2H-naphtho[2,3-d]-1,3-dioxol-5-ol 
• 27673-48-9 5,8-dihydro-1-naphthol 
• 35697-13-3 6,7-epoxy-5,6,7,8-tetrahydro-naphthalen-1-ol 

Relevant articles and documents

ACYL GUANIDINE SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD

Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C-R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; and R1, R2, R3 and R4 are as defined herein, and where X is N, R1 is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above acyl guanidines.

Esters of tetrahydronaphthyloxy-aminopropanols

Compounds having the formula STR1 wherein R1 is lower alkyl; R3, R4, R5, R6, and R7 are the same or different and are hydrogen or lower alkyl; R8, R9, and R10 are the same or different and are hydrogen, lower alkyl, lower alkoxy or cycloalkyl; and R11 is acyl; are useful in the treatment of coronary diseases.