35697-16-6

Usage

Uses

Used in Pharmaceutical Industry:
cis-5,6,7,8-tetrahydronaphthalene-1,6,7-triol is used as an intermediate for the preparation of nondepressant β-adrenergic blocking agents. These agents are crucial in the treatment of various cardiovascular conditions, such as hypertension, angina, and arrhythmias. cis-5,6,7,8-tetrahydronaphthalene-1,6,7-triol's unique structure allows for the development of drugs with minimal side effects on the central nervous system, making it a valuable component in the synthesis of these medications.

InChI:InChI=1/C10H12O3/c11-8-3-1-2-6-4-9(12)10(13)5-7(6)8/h1-3,9-13H,4-5H2

Upstream product

• 52187-19-6 3a-9a-cis-3a,4,9,9a-tetrahydro-2,2-dimethyl-2H-naphtho[2,3-d]-1,3-dioxol-5-ol 
• 27673-48-9 5,8-dihydro-1-naphthol 
• 35697-13-3 6,7-epoxy-5,6,7,8-tetrahydro-naphthalen-1-ol 

Relevant academic research and scientific papers

ACYL GUANIDINE SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD

Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C-R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; and R1, R2, R3 and R4 are as defined herein, and where X is N, R1 is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above acyl guanidines.

Nondepressant β-adrenergic blocking agents. I Substituted 3-amino-1-(5, 6, 7, 8-tetrahydro-1-naphthoxy)-2-propanols

A series of 3-amino-1-(5,6,7,8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for β-adrenergic blocking activity and direct myocardial depressant action. The cis- and trans-diols 12-15 were found to retain the β-blocking potency of propranolol but to lack its myocardial depressant action. Compound 15 (nadolol) is currently undergoing extensive clinical evaluation as a potential antianginal, antiarrhythmic, and antihypertensive agent.

Esters of tetrahydronaphthyloxy-aminopropanols

Compounds having the formula STR1 wherein R1 is lower alkyl; R3, R4, R5, R6, and R7 are the same or different and are hydrogen or lower alkyl; R8, R9, and R10 are the same or different and are hydrogen, lower alkyl, lower alkoxy or cycloalkyl; and R11 is acyl; are useful in the treatment of coronary diseases.

Tetrahydronaphthyloxy-aminopropanols and salts thereof

This invention relates to new tetrahydronaphthyloxy-aminopropanols and related compounds of the formula SPC1 And to salts of such compounds, which are useful in coronary diseases.