35700-22-2

Usage

Type

Synthetic derivative of naturally occurring prostaglandin F2alpha

Receptor

Potent and selective agonist for the FP receptor

Physiological processes involved

Smooth muscle contraction and inflammation

Usage

Commonly used in scientific research to study the effects of prostaglandin F2alpha on biological systems

Role

Involved in reproductive and cardiovascular disorders

Therapeutic applications

Potential use in the treatment of glaucoma and as an abortifacient.

Upstream product

• 41691-84-3 (5Z,9α,11α,13E)-15-methyl-9,11,15-trihydroxy-prosta-5,13-diene-1-carboxylic acid 
• 74-88-4 methyl iodide 
• 35864-81-4 (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((E)-(R)-3-hydroxy-3-methyl-oct-1-enyl)-cyclopentyl]-hept-5-enoic acid 
• 31753-00-1 [1,1'-bisphenyl]-4-carboxylic acid (3aR,4R,5R,6aS)-hexahydro-2-oxo-4-[(1E)-3-oxo-1-octen-1-yl]-2H-cyclopenta[b]furan-5-yl ester 
• 42743-23-7 [1,1'-bisphenyl]-4-carboxylic acid (3aR,4R,5R,6aS)-hexahydro-2-oxo-4-[(1E)-3-hydroxy-3-methyl-1-octen-1-yl]-2H-cyclopenta[b]furan-5-yl ester 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF CARBOPROST AND ITS TROMETHAMINE SALT

The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silicagel chromatography and the salt formation is carried out by using solid tromethamine base.

IMPROVED METHOD FOR THE WITTIG REACTION IN THE PREPARATION OF CARBOPROST

A process for the preparation of carboprost methyl ester (figure (10)).

8β,12α,15β-PGF2 β Compounds

This invention is a group of 8-beta, 12-alpha-PG2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.