357155-86-3

Basic information

• Product Name: methyl 4-[(1E)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]benzoate
• Synonyms: benzoic acid, 4-[(1E)-3-(4-methoxyphenyl)-3-oxo-1-propen-1-yl]-, methyl ester
• CAS NO: 357155-86-3
• Molecular Formula: C₁₈H₁₆O₄
• Molecular Weight: 296.3172
• Mol File: 357155-86-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 471.7°C at 760 mmHg
• Flash Point: 209.3°C
• Density: 1.177g/cm³
• Vapor Pressure: 4.55E-09mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: methyl 4-[(1E)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-[(1E)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]benzoate(357155-86-3)
• EPA Substance Registry System: methyl 4-[(1E)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]benzoate(357155-86-3)

Safety Data

• Hazardous Substances Data: 357155-86-3(Hazardous Substances Data)

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1571-08-0 methyl 4-formylbenzoate 
• 20912-79-2 4-methoxyphenacylidene dimethylsulphurane 
• 125587-45-3 methyl 4-[(2-tosylhydrazono)methyl]benzoate 
• 186581-53-3 diazomethane 
• 106315-53-1 4-[3-(4-methoxyphenyl)-3-oxo-propenyl]benzoic acid 

Relevant articles and documents

Alkene Synthesis by Photo-Wolff-Kischner Reaction of Sulfur Ylides and N-Tosylhydrazones

A visible-light-driven and room temperature photo-Wolff-Kischner reaction of sulfur ylides and N-tosylhydrazones has been developed for the first time to provide modular access to alkene synthesis. The high functional group tolerance and broad substrate scope were demonstrated by more than 60 examples. Both E- and Z-olefinic stereochemistry in the products could be controlled with excellent stereoselectivity. A series of mechanistic studies support that the reaction should proceed through a radical-carbanion crossover pathway, specifically involving addition of photo-generated sulfur ylide radical cations to N-tosylhydrazones to form carbanions and subsequent Wolff-Kischner process.

CBr4 as a Halogen Bond Donor Catalyst for the Selective Activation of Benzaldehydes to Synthesize α,β-Unsaturated Ketones

CBr4 has been employed as a halogen bond donor catalyst for the selective activation of aldehyde, to achieve an efficient solvent- and metal-free CC bond forming reaction in the presence of strong acid sensitive groups such as methoxy, cyanide, ester, and ketal for the synthesis of α,β-unsaturated ketones. This unique capability of CBr4 to act as a halogen bond donor has been explored and established using UV-vis as well as IR spectroscopy. Moreover, this unprecedented methodology enables the synthesis of the pharmaceutically important molecule licochalcone A.