357156-82-2

Upstream product

• 1027985-96-1 2,2-dimethyl-6-(2-oxo-2-cyclohexyl)-4H-1,3-dioxin-4-one 
• 2043-61-0 cyclohexanecarbaldehyde 
• 412277-09-9 6-(2-cyclohexyl-2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxin-4-one 

Downstream Products

• 706817-64-3 4-bromo-6-cyclohexyl-pyrane-2-one 
• 1304105-24-5 C₁₁H₁₃ClO₂ 
• 1304104-56-0 6-cyclohexyl-4-[(4-methoxyphenyl)amino]-2H-pyran-2-one 
• 357156-76-4 6-cyclohexyl-4-methoxy-3-phenylsulfinylmethyl-2H-pyran-2-one 
• 357156-72-0 6-cyclohexyl-4-methoxy-3-phenylthiomethyl-2H-pyran-2-one 

Relevant academic research and scientific papers

Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity

4-Amino-2H-benzo[h]chromen-2-one (ABO) and 4-amino-7,8,9,10-tetrahydro-2H- benzo[h]chromen-2-one (ATBO) analogs were found to be significant in vitro anticancer agents in our previous research. Our continuing study has now discovered a new simplified (monocyclic rather than tricyclic) class of cytotoxic agents, 4-amino-2H-pyran-2-one (APO) analogs. By incorporating various substituents on the pyranone ring, we have established preliminary structure-activity relationships (SAR). Analogs 19, 20, 23, and 26-30 displayed significant tumor cell growth inhibitory activity in vitro. The most active compound 27 exhibited ED50 values of 0.059-0.090 μM.

SUBSTITUTED 1H-PYRIDINE-2-ONE DERIVATIVES

The present invention relates to substituted 1H-pyridine-2-one derivatives of formula (1) and pharmaceutically acceptable salts thereof, which are useful for the treatment of chronic obstructive pulmonary disease, asthma, chronic bronchitis, psoriasis, ul

Synthesis of 6-substituted 4-hydroxy-2-pyrones from aldehydes by addition of an acetoacetate equivalent, Dess-Martin oxidation and subsequent cyclization

A three step procedure for the synthesis of 6-substituted 4-hydroxy-2-pyrones 2 from aldehydes 1 is described. An acetoacetate equivalent 3 was added to the corresponding aldehyde (10 examples) in a vinylogous Mukaiyama aldol addition (72-99%). The intermediate alcohols 4 were oxidized to the ketones 5 using the Dess-Martin method (67%-quant,). A final thermal cyclization of compounds 5 yielded the title compounds 2 (61-92%; 40-85% overall).