35716-49-5Relevant academic research and scientific papers
Synthesis, characterization and catalytic properties of diorganotin derivatives. Crystal and molecular structure of the first complex of 2-(2-methyl-3-nitroanilino)benzoic acid of 1,2:3,4-di-μ2-2-(2-methyl-3-nitroanilino)benzoato-O,O-1,3-bis-2-(2-methyl-3-nitroanilino)benzoato-O-1,2,4:2,3,4-di-μ3-oxo-tetrakis[di-methyltin(IV)]
Dokorou, Vaso N.,Kovala-Demertzi, Dimitra,Louloudi, Maria,Silvestru, Anca,Demertzis, Mavroudis A.
experimental part, p. 3587 - 3592 (2009/02/07)
The complexes [Me2(MNAB)SnOSn(MNAB)Me2]2 (2) and [Me2Sn(MNAB)2] (3), where HMNAB is 2-(2-methyl-3-nitroanilino)benzoic acid, (1), have been prepared and structurally characterized by means of vibrational, 1H and 13C NMR spectroscopies. The crystal structure of [Me2(MNAB)SnOSn(MNAB)Me2]2 has been determined by X-ray crystallography. Three distannoxane rings are present to the dimeric tetraorganodistannoxane of planar ladder arrangement. The structure is centro-symmetric and features a central rhombus Sn2O2 unit with two additional tin atoms linked at the O atoms. Six-coordinated tin centers are present in the dimmer distannoxane. This structure is self-assembled in one dimensional infinite chain via intermolecular hydrogen bonds, π → π and C-H → π stacking interactions. The polar imino hydrogen atom participates in intramolecular hydrogen bonds. The catalytic activity of the prepared complexes in transesterification reactions has been studied. The diorganotin complexes efficiently catalyze the transesterification reaction of 2-phenylethanol without addition of free ligand or any promoting additive.
Structure-activity relationships in a series of anti-inflammatory N-arylanthranilic acids
Kaltenbronn,Scherrer,Short,Jones,Beatty,Saka,Winder,Wax,Williamson
, p. 621 - 627 (2007/10/02)
A large series of N-arylanthranilic acids has been prepared. Many of these compounds show high anti-inflammatory activity as measured by the anti-UV-erythema test. From this series have come the clinically useful nonsteroidal anti-inflammatory agents, flufenamic acid (Arlef), mefenamic acid (Ponstel), and the latest and most potent agent, N-(2,6-dichloro-m-tolyl)anthranilic acid (meclofenamic acid, Meclomen = the sodium salt). The structure-activity relationships of this series is discussed and a graphical representation is presented which allows the prediction of activity of new agents.
