357193-01-2

Upstream product

• 36924-81-9 ethyl 2-(4-aminophenyl)-2-methylpropanoate 
• 83397-45-9 ethyl 2-methyl-2-(4-nitrophenyl)propanoate 

Downstream Products

• 1076220-88-6 ethyl 2-(4-amino-3-bromo-5-iodophenyl)-2-methylpropanoate 
• 1076220-89-7 ethyl 2-(4-amino-3-bromo-5-{[4-(trifluoromethoxy)phenyl]ethynyl}phenyl)-2-methylpropanoate 
• 1076220-90-0 ethyl 2-{7-bromo-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoate 
• 1076220-91-1 ethyl 2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoate 
• 1076220-92-2 2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid 
• 1076219-30-1 2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-N-(tert-butyl)-2-methylpropionamide 

Relevant academic research and scientific papers

A convergent synthesis of (S)-β-methyl-2-aryltryptamine based gonadotropin releasing hormone antagonists

A practical synthesis of (S)-β-methyl-2-aryltryptamine based gonadotropin releasing hormone antagonists which features a palladium-catalyzed Larock indole synthesis and a palladium-catalyzed Suzuki-Miyaura sequence to install the 2-position aryl substitue