357212-13-6

Basic information

• Product Name: 2-acetyl-6-phenyl-hexanoic acid ethyl ester
• Synonyms: 2-acetyl-6-phenyl-hexanoic acid ethyl ester
• CAS NO: 357212-13-6
• Molecular Weight: 262.349
• Mol File: 357212-13-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-acetyl-6-phenyl-hexanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetyl-6-phenyl-hexanoic acid ethyl ester(357212-13-6)
• EPA Substance Registry System: 2-acetyl-6-phenyl-hexanoic acid ethyl ester(357212-13-6)

Safety Data

• Hazardous Substances Data: 357212-13-6(Hazardous Substances Data)

Upstream product

• 13633-25-5 1-Bromo-4-phenylbutane 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 768-56-9 4-Phenylbut-1-ene 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 14171-88-1 7-phenylheptan-2-one 

Relevant articles and documents

Hydroalkylation of Unactivated Olefins via Visible-Light-Driven Dual Hydrogen Atom Transfer Catalysis

Radical hydroalkylation of olefins enabled by hydrogen atom transfer (HAT) catalysis represents a straightforward means to access C(sp3)-rich molecules from abundant feedstock chemicals without the need for prefunctionalization. While Giese-type hydroalkylation of activated olefins initiated by HAT of hydridic carbon-hydrogen bonds is well-precedented, hydroalkylation of unactivated olefins in a similar fashion remains elusive, primarily owing to a lack of general methods to overcome the inherent polarity-mismatch in this scenario. Here, we report the use of visible-light-driven dual HAT catalysis to achieve this goal, where catalytic amounts of an amine-borane and an in situ generated thiol were utilized as the hydrogen atom abstractor and donor, respectively. The reaction is completely atom-economical and exhibits a broad scope. Experimental and computational studies support the proposed mechanism and suggest that hydrogen-bonding between the amine-borane and substrates is beneficial to improving the reaction efficiency.