357263-42-4

Basic information

• Product Name: 1H-Pyrrolo[3,2-b]pyridine,7-methyl-(9CI)
• Synonyms: 1H-Pyrrolo[3,2-b]pyridine,7-methyl-(9CI);7-Methyl-5-Azaindole;7-Methyl-4-azaindole;7-Methyl-1H-pyrrolo[3,2-c]pyridine
• CAS NO: 357263-42-4
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.165
• Product Categories: PYRIDINE
• Mol File: 357263-42-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 281℃
• Flash Point: 125℃
• Appearance: /
• Density: 1.186
• CAS DataBase Reference: 1H-Pyrrolo[3,2-b]pyridine,7-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[3,2-b]pyridine,7-methyl-(9CI)(357263-42-4)
• EPA Substance Registry System: 1H-Pyrrolo[3,2-b]pyridine,7-methyl-(9CI)(357263-42-4)

Safety Data

• Hazardous Substances Data: 357263-42-4(Hazardous Substances Data)

Usage

Uses

7-Methyl-1H-pyrrolo[3,2-b]pyridine is used as reagent in organic synthesis including that of 1,4-azaindoles which are used as antimycobacterial agents. It is also used in the preparation of antiviral azaindole derivatives.

Upstream product

• 98198-48-2 2-amino-5-bromo-4-methylpyridine 

Downstream Products

• 1615714-14-1 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid 
• 1615714-13-0 methyl 1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylate 
• 1615714-04-9 N-(cyclopropylmethyl)-1-(5-fluoro-2-methoxybenzyl)-7-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide 
• 1190312-40-3 3-iodo-7-methyl-1H-pyrrolo[3,2-b]pyridine 

Relevant articles and documents

Scalable synthesis and properties of 7-methyl-4-azaindole

An approach to the synthesis of 7-methyl-4-azaindole, which is a valuable building block for drug discovery programs, is described. The method relies on using a bromine atom as a 'place holding group' for one of the carbon atoms of the pyridine ring throughout the reaction sequence, and it is removed only upon the final reductive cyclization leading to the azaindole ring. Exhaustive hydrogenation of the target product proceeds in a diastereoselective manner and leads to a bicyclic conformationally restricted diamine derivative.