357263-49-1

Basic information

• Product Name: METHYL 7-AZAINDOLE-3-GLYOXYLATE
• Synonyms: METHYL (7-AZAINDOL-3-YL)OXOACETATE;METHYL 7-AZAINDOLE-3-GLYOXYLATE;ALFA-OXO-1H-PYRROLO-[2,3B]PYRIDINE-3-ACETIC ACID METHYL ESTER;1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, a-oxo-, methyl ester;Methyl α-oxo-7-azaindole-3-acetate;Oxo-(1H-pyrrolo[2,3-b]pyridin-3-yl)-acetic acid methyl ester;methyl 2-oxo-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)acetate;α-Oxo-1H-pyrrolo[2,3-b]pyridine-3-acetic Acid Methyl Ester
• CAS NO: 357263-49-1
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 204.18
• Product Categories: Indole Derivatives;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 357263-49-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 165-168°C
• Boiling Point: 399.1 °C at 760 mmHg
• Flash Point: 195.1 °C
• Appearance: /
• Density: 1.392g/cm³
• Vapor Pressure: 1.41E-06mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: 2-8°C
• PKA: 11.42±0.40(Predicted)
• CAS DataBase Reference: METHYL 7-AZAINDOLE-3-GLYOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 7-AZAINDOLE-3-GLYOXYLATE(357263-49-1)
• EPA Substance Registry System: METHYL 7-AZAINDOLE-3-GLYOXYLATE(357263-49-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 357263-49-1(Hazardous Substances Data)

Usage

Chemical Properties

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Uses

An azaindole derivative as CRTH2 receptor antagonist.

InChI:InChI=1/C10H8N2O3/c1-15-10(14)8(13)7-5-12-9-6(7)3-2-4-11-9/h2-5H,1H3,(H,11,12)

Upstream product

• 271-63-6 7-Azaindole 
• 5781-53-3 monomethyl oxalyl chloride 

Downstream Products

• 169030-84-6 methyl (1H-pyrrolo[2,3-b]pyridin-3-yl)acetate 
• 357262-96-5 4-benzoyl-2-(R)-methyl-1-[(4-nitro-7-oxido-1H-pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]piperazine 
• 357263-05-9 4-benzoyl-1-[(4-methoxy-7-oxido-1H-pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2-(R)-methylpiperazine 
• 357263-13-9 4-benzoyl-1-[(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2-(R)-methylpiperazine 
• 357262-90-9 4-benzoyl-2-(R)-methyl-1-[(7-oxido-1H-pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]piperazine 
• 357262-60-3 (R)-1-(4-benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione 
• 626604-26-0 (3-{3-[4-(2-methoxy-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-pyrrolo[2,3-b]pyridin-1-yl}-propyl)-carbamic acid tert-butyl ester 
• 729609-97-6 methanesulfonic acid 3-{3-[4-(2-chloro-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-pyrrolo[2,3-b]pyridin-1-yl}-propyl ester 
• 626604-30-6 3-[1-(3-aminopropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione 
• 626603-93-8 3-(2-chlorophenyl)-4-[1-(3-hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrole-2,5-dione 
• 626604-79-3 2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-acetamide 

Relevant articles and documents

TARGETED BIFUNCTIONAL DEGRADERS

The present invention provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of certain circulating proteins. In another aspect, the present invention provides bifunctional compounds that can be used to promote or enhance degradation of certain autoantibodies. In certain embodiments, treatment or management of a disease and/or disorder requires degradation, removal, or reduction in concentration of the circulating protein or the autoantibody in the subject. Thus, in certain embodiments, administration of a compound of the invention to the subject removes or reduces the circulation concentration of the circulating protein or the autoantibody, thus treating, ameliorating, or preventing the disease and/or disorder. In certain embodiments, the circulating protein is TNF.

AZAINDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS

Compounds of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2 -mediated diseases such as asthma.

ORGANIC COMPOUNDS

There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.