357263-50-4Relevant academic research and scientific papers
Prodrugs of piperazine and substituted piperidine antiviral agents
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Page/Page column 24; 25, (2010/02/14)
This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
An effective procedure for the acylation of azaindoles at C-3
Zhang, Zhongxing,Yang, Zhong,Wong, Henry,Zhu, Juliang,Meanwell, Nicholas A.,Kadow, John F.,Wang, Tao
, p. 6226 - 6227 (2007/10/03)
Conditions for attachment of acetyl chloride, benzoyl chloride, and chloromethyl oxalate to the 3-position of 4-, 5-, 6-, or 7-azaindoles were explored. Best results were achieved with an excess of AlCl3 in CH2Cl2 followed
Antiviral azaindole derivatives
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, (2008/06/13)
The present invention is directed to a series of chemical entities that express HIV-1 inhibitory activities.
Antiviral azaindole derivatives
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, (2008/06/13)
The present invention is directed to a series of chemical entities that express HIV-1 inhibitory activities.
