35728-20-2Relevant academic research and scientific papers
CYCLIZATION OF 1-CYANOACETYL-4-SUBSTITUTED THIOSEMICARBAZIDES TO 1,2,4-TRIAZOLE OR 1,3,4-THIADIAZOLE DERIVATIVES
Dobosz, Maria,Pachuta-Stec Anna
, p. 103 - 112 (2007/10/02)
In the reaction of hydrazide of cyanoacetic acid with isothiocyanates 1-cyanoacetyl-4-substituted thiosemicarbazides were obtained.The cyclization of these derivatives with 2percent or 10percent aqueous sodium hydroxide has led to formation of new derivatives of 1,2,4-triazole-3-acetic acid .The cyclization of compounds with acetic acid or the cyclization of compounds with 3N hydrochloric acid has led to formation 2-(R-amino)-5-cyanomethyl-1,3,4-thiadiazoles , but the reactions of compounds with boiling 3N hydrochloric acid for 5 h has led to formation dihydrochlorides of amides of 2-(R-amino)-1,3,4-thiadiazole-5-acetic acids (XXXIV-XXXVI>.Keywords: derivatives of 1,2,4-triazole, derivatives of 1,3,4-thiadiazole, synthesis, elemental and spectral analysis.
REACTIONS OF ACYLTHIOSEMICARBAZIDES WITH β-DIKETONES: NOVEL SYNTHESIS OF N-(1-PYRIDYL)THIOUREA DERIVATIVES
Elgemeie, Galal E. H.,Hussain, Badria A. W.
, p. 601 - 611 (2007/10/02)
The reaction of 1-cyanoacetyl-4-arylthiosemicarbazides with β-diketones was studied as a new route for the synthesis of N-(1-pyridyl)thiourea derivatives.The latter compounds could also be prepared via reaction of the corresponding N-aminopyridines with a
