35728-21-3

Upstream product

• 140-87-4 Cyanoacetohydrazide 
• 1985-12-2 4-Bromophenyl isothiocyanate 

Downstream Products

• 73218-06-1 [4-(4-bromo-phenyl)-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]-acetonitrile 

Relevant academic research and scientific papers

CYCLIZATION OF 1-CYANOACETYL-4-SUBSTITUTED THIOSEMICARBAZIDES TO 1,2,4-TRIAZOLE OR 1,3,4-THIADIAZOLE DERIVATIVES

In the reaction of hydrazide of cyanoacetic acid with isothiocyanates 1-cyanoacetyl-4-substituted thiosemicarbazides were obtained.The cyclization of these derivatives with 2percent or 10percent aqueous sodium hydroxide has led to formation of new derivatives of 1,2,4-triazole-3-acetic acid .The cyclization of compounds with acetic acid or the cyclization of compounds with 3N hydrochloric acid has led to formation 2-(R-amino)-5-cyanomethyl-1,3,4-thiadiazoles , but the reactions of compounds with boiling 3N hydrochloric acid for 5 h has led to formation dihydrochlorides of amides of 2-(R-amino)-1,3,4-thiadiazole-5-acetic acids (XXXIV-XXXVI>.Keywords: derivatives of 1,2,4-triazole, derivatives of 1,3,4-thiadiazole, synthesis, elemental and spectral analysis.