357282-03-2

Upstream product

• 357282-00-9 1-bromo-3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-D-ribofuranosyl cyanide 
• 357281-99-3 3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-D-ribofuranosyl cyanide 
• 3601-90-9 5-chloro-2-(((4-chlorobenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 357282-02-1 2-nitrobenzyl 1'-cyano-2'-deoxy-D-ribofuranoside 

Relevant academic research and scientific papers

Site-specific generation of deoxyribonolactone lesions in DNA oligonucleotides

(matrix presented) An efficient method for the site-specific generation of 2-deoxyribonolactone oxidative DNA damage lesions from a "photocaged" nucleoside analogue was developed. A nucleoside phosphoramidite bearing a C-1′ nitrobenzyl cyanohydrin was prepared and incorporated into DNA oligonucleotides using automated DNA synthesis. The caged analogue, which was stable in aqueous solution, was converted to the 2-deoxyribonolactone lesion by UV irradiation. DNA containing the caged analogue and the deoxyribonolactone site were characterized by electrospray mass spectrometry (ES-MS).