35729-77-2Relevant academic research and scientific papers
Convenient titanium(III)-catalyzed synthesis of cyclic aminoketones and pyrrolidinones - Development of a formal [4+1] cycloaddition
Frey, Georg,Luu, Hieu-Trinh,Bichovski, Plamen,Feurer, Markus,Streuff, Jan
, p. 7131 - 7134 (2013)
Have it both ways: α-Aminated ketones can be prepared by the titanium(III)-catalyzed reductive radical cyclization of iminonitriles. Depending on the position of the nitrile at the imine carbon or nitrogen, cyclic aminoketones or pyrrolidin-3-ones with a tetrasubstituted α-carbon can be formed in up to quantitative yield. In the latter case, the imine condensation and TiIII catalysis correspond to a formal [4+1] cycloaddition. Copyright
