357400-75-0

Upstream product

• 109-77-3 malononitrile 
• 213256-73-6 methyl p-[N-(2-methoxycarbonylallyl)amino]benzoate 
• 4224-69-5 methyl 2-(bromomethyl)propenoate 
• 619-45-4 4-methoxycarbonyl aniline 

Downstream Products

• 213256-77-0 methyl 4-[N-(2,4-diamino-7-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylmethyl)amino]benzoate 
• 213256-85-0 (S)-2-{4-[(2,4-Diamino-7-oxo-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid dimethyl ester 
• 213256-80-5 4-[(2,4-Diamino-7-oxo-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoic acid 

Relevant academic research and scientific papers

Synthesis and biological activity of 7-oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF) and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)

We recently described the syntheses of 12a-c, 4-amino-7-oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF), and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), in six steps from commercially available p-substituted methyl benz

Selective reduction of the 7-oxo group in pyrido[2,3d]pyrimidine-4,7- diones: A new synthetic approach to 5,10-dideazatetrahydrofolic acid (DDATHF)

A selective reduction of the carbonyl group at C7 with borane in THF is accomplished for 2,4-diamino-7-oxo and 2-amino-4,7-dioxo substituted pyridopyrimidines (7a-c) and (13a-c) respectively, the ester group remaining unaltered in both cases. The synthesi