357416-38-7Relevant academic research and scientific papers
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
Cheshire, David R.,?berg, Anders,Andersson, Gunilla M.K.,Andrews, Glen,Beaton, Haydn G.,Birkinshaw, Timothy N.,Boughton-Smith, Nigel,Connolly, Stephen,Cook, Tony R.,Cooper, Anne,Cooper, Sally L.,Cox, David,Dixon, John,Gensmantel, Nigel,Hamley, Peter J.,Harrison, Richard,Hartopp, Paul,K?ck, Helena,Leeson, Paul D.,Luker, Timothy,Mete, Antonio,Millichip, Ian,Nicholls, David J.,Pimm, Austen D.,St-Gallay, Steve A.,Wallace, Alan V.
, p. 2468 - 2471 (2011/06/17)
By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.
Novel phenylheteroalkylamine derivatives
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, (2008/06/13)
There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
