357424-12-5

Basic information

• Product Name: 5,9-Methanoimidazo[4,5-h][3]benzazepine,1,5,6,7,8,9-hexahydro-(9CI)
• Synonyms: 5,9-Methanoimidazo[4,5-h][3]benzazepine,1,5,6,7,8,9-hexahydro-(9CI)
• CAS NO: 357424-12-5
• Molecular Formula: C12H13N3
• Molecular Weight: 199.25
• Product Categories: CYCLOPENTANE;BENZIMIDAZOLE
• Mol File: 357424-12-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5,9-Methanoimidazo[4,5-h][3]benzazepine,1,5,6,7,8,9-hexahydro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5,9-Methanoimidazo[4,5-h][3]benzazepine,1,5,6,7,8,9-hexahydro-(9CI)(357424-12-5)
• EPA Substance Registry System: 5,9-Methanoimidazo[4,5-h][3]benzazepine,1,5,6,7,8,9-hexahydro-(9CI)(357424-12-5)

Safety Data

• Hazardous Substances Data: 357424-12-5(Hazardous Substances Data)

Upstream product

• 230615-64-2 5,7,13-triazatetracyclo[9.3.1.02,10.04,8]pentadeca-2⁽¹⁰⁾,3,5,8-tetraene-13-carboxylic acid tert-butyl ester 

Relevant articles and documents

3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

3,5-Bicyclic aryl piperidines are a new class of high-affinity α4β2 nicotinic receptor agents. We have sought nicotinic receptor partial agonists of the α4β2 nicotinic acetylcholine receptor for smoking cessation, and a number of compounds fulfill potency, selectivity, and efficacy requirements in vitro. In vivo, selected agents demonstrate potent partial agonist efficacy on the mesolimbic dopamine system, a key measure of therapeutic potential for smoking cessation.