357442-18-3

Upstream product

• 288-88-0 1,2,4-Triazole 
• 150966-37-3 3-(2,3-O-Isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazolo<4,5-d>pyrimidin-7(6H)-one 
• 72741-18-5 tri(1H-1,2,4-triazol-1-yl)phosphine oxide 

Downstream Products

• 155666-80-1 7-Amino-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)-isothiazolo<4,5-d>pyrimidine 

Relevant academic research and scientific papers

Efficient synthesis of fused isothiazolo C-nucleosides. III. Synthesis of 7-substituted isothiazolo [4,5-d] pyrimidine C-nucleosides*

The Divakar-Reese procedure has been successfully applied for transforming 7-oxo-isothiazolo[4,5-d]pyrimidine C-nucleosides (4a,b, 5a,b, 6a) via 1,2,4-triazol-1-yl intermediates (7a,b, 8a,b) into various 7-substituted C-nucleosides 15a,b, 16a,b, 17a, 18a, 19a,b, 20a,b; their subsequent deprotection provides novel types of unusual C-glycosides 22b, 23a, 24a,b, 25b, 26b. C-Nucleosides, possessing on its heterocyclic base other than naturally occuring oxo- or amino substituents, are important model compounds for biological or medicinal studies (2,3). We want to report on the synthesis of novel 7-substituted isothiazolo = [4,5-d]pyrimidine C-nucleosides. As we could show in previous papers (1,4), there exists a simple approach to the protected C-glycosides 4-6.