35761-26-3Relevant articles and documents
Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand
Aschmann, Dennis,Bayer, Peter,Beuck, Christine,Ehlers, Martin,Giese, Michael,Killa, Matthias,Knauer, Shirley K.,Meiners, Annika,Mertel, Marcel,Schmuck, Carsten,Vallet, Cecilia
, p. 5567 - 5571 (2020)
The protein Survivin is highly upregulated in most cancers and considered to be a key player in carcinogenesis. We explored a supramolecular approach to address Survivin as a drug target by inhibiting the protein–protein interaction of Survivin and its fu
PYRROLOBENZODIAZEPINE DIMER PRECURSOR AND LIGAND-LINKER CONJUGATE COMPOUND THEREOF
-
, (2020/02/18)
The present invention relates to a pyrrolobenzodiazepine dimer prodrug and a ligand-linker conjugate compound thereof, a composition containing these, and therapeutic use thereof particularly as an anticancer drug. The stability of the compounds themselves and the stability thereof in plasma are excellent and the compounds are advantageous in terms of manifestation of toxicity, and thus the compounds are industrially useful in that it is possible to target proliferative diseases such as cancer, to perform a specific treatment, to maximize the drug efficacy, and to minimize the occurrence of side effects.
Phosphate bioisostere containing amphiphiles: A novel class of squaramide-based lipids
Saha, Abhishek,Panda, Subhankar,Paul, Saurav,Manna, Debasis
, p. 9438 - 9441 (2016/07/29)
We describe a novel class of amphiphiles with squaramide moiety as a phosphate bioisostere. Most synthesized squaramide-based amphiphiles have the favorable physicochemical properties of lipids, such as: formation of stable liposomes or giant unilamellar vesicles in aqueous solution, high phase-transition temperature, low vesicle leakage and phospholipase resistance properties.