357624-01-2Relevant academic research and scientific papers
A new strategy for synthesis of the dinucleotide pdCpA: A convenient method for the deprotection of cyanoethyl, TBDMS, and benzoyl groups in one step at high pressure
Kataoka, Masanori,Fukui, Chiharu,Mimoto, Akiko,Kuge, Hideaki,Honke, Koichi,Kotsuki, Hiyoshizo
, p. 1164 - 1169 (2015)
A new convenient method for the preparative-scale synthesis of the dinucleotide pdCpA was developed. This method takes advantage of the complete deprotection of cyanoethyl, TBDMS, and benzoyl groups in one step under high-pressure conditions in the final stage of the synthetic sequence.
An improved synthesis of the dinucleotides pdCpA and pdCpdA
Zhu, Xue-Feng,Scott, A. Ian
, p. 197 - 211 (2007/10/03)
An improved route was developed for the preparation of the dinucleotide hybrid 5′-O-phosphoryl-2′-deoxycytidylyl-(3′ → 5′)adenosine (pdCpA) 7. This simple and concise synthesis involves the successive coupling of 2-cyanoethyl N, N, N′, N′-tetra- isopropylphosphorodiamidite with 4-N-benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxy-cytidine 1 and 6-N,6-N,2′-O,3′-O-tetrabenzoyladenosine 2 as the key step. Some dinucleotide derivatives bearing different protecting groups were also synthesized and the selective deprotection conditions were studied in detail. The utility and efficiency of this approach has been further demonstrated by its application to the synthesis of total DNA dinucleotide pdCpdA 17 and total RNA dinucleotide 21.
