35771-65-4

Usage

Uses

Used in Pharmaceutical Industry:
5-(2-FURYL)-2,4-DIHYDRO-1,2,4-TRIAZOLE is used as a potential therapeutic agent for various medical conditions due to its anti-inflammatory, anti-cancer, and neuroprotective properties. It is being investigated for its efficacy in treating diabetes and cardiovascular diseases, as well as for its potential in the development of new antibiotics and antifungal drugs.
Used in Anti-Inflammatory Applications:
In the field of anti-inflammatory treatments, 5-(2-FURYL)-2,4-DIHYDRO-1,2,4-TRIAZOLE is used as an agent to reduce inflammation, potentially offering relief for conditions characterized by excessive or chronic inflammation.
Used in Anticancer Applications:
5-(2-FURYL)-2,4-DIHYDRO-1,2,4-TRIAZOLE is used as an anticancer agent, showing promise in preclinical studies for its ability to target and inhibit the growth of cancer cells, making it a candidate for further research and development in oncology.
Used in Neuroprotective Applications:
In the area of neuroprotection, 5-(2-FURYL)-2,4-DIHYDRO-1,2,4-TRIAZOLE is used as a compound to protect neurons from damage or degeneration, which could be beneficial in the treatment of neurodegenerative diseases.
Used in Antimicrobial and Antifungal Development:
5-(2-FURYL)-2,4-DIHYDRO-1,2,4-TRIAZOLE is used as a potential antimicrobial and antifungal agent, indicating its use in the development of new drugs to combat resistant strains of bacteria and fungi, addressing the growing need for novel treatments in infectious disease management.

InChI:InChI=1/C6H5N3OS/c11-6-7-4-9(8-6)5-2-1-3-10-5/h1-4H,(H,8,11)

Upstream product

• 35771-64-3 1-(2-furoyl)-3-thiosemicarbazide 
• 26172-44-1 2-furoylisothiocyanate 
• 527-69-5 2-furancarbonyl chloride 
• 1147550-11-5 ammonium thiocyanate 
• 3326-71-4 2-furoic acid hydrazide 

Downstream Products

• 30452-55-2 (5-furan-2-yl-1H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid 
• 30502-39-7 α-<5-(2-Furyl)-1,2,4-triazol-3-ylthio>acethydrazid 
• 34698-45-8 3-furan-2-yl-5-phenyl-thiazolo[2,3-c][1,2,4]triazole 

Relevant academic research and scientific papers

Triazole neuraminidase inhibitor as well as preparation method and application thereof

The invention relates to a triazole neuraminidase inhibitor and a preparation method and application thereof, and the inhibitor has the structure shown in the formula (I). The preparation method comprises: (1) forming a reaction system with substituted aniline and chloroacetyl chloride to obtain the intermediate of the formula (II). (2) A reaction system is formed by dissolving furanoyl chloride and thiosemicarbazone in an organic solvent to obtain the intermediate of formula (III). (3) (2) The obtained intermediate of formula (III) is dissolved in sodium hydroxide solution to form a reaction system to obtain the intermediate of formula (IV). (4) (3) The intermediate of formula (IV) obtained in Step (1) and the sodium hydroxide solution of formula (II) obtained in step (a) are dissolved in an organic solvent, and the reaction is post-treated to the inhibitor shown in formula (I). The compound disclosed by the invention is novel in structure, has good neuraminidase inhibitory activity and can be used for preparing a medicament for inhibiting neuraminidase activity.

Nano nickel [1,2,4]-triazole-3-thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

A series of new 1,2,4-triazole-3-thiones were synthesized by calm, benign, no risk, eco-friendly, and energy efficient sequential reaction methodology like grinding and ultrasonic (US). In addition, 1,2,4-triazoles were prepared under conventional method and comparative study was done. The synthesized 1,2,4-triazoles were complexed with Ni(II) to produce nanoparticles complexes (NPC's) with average particle size vary from 55 to 100 nm (using scanning electron microscope technique) with good yields via both US and conventional techniques. X-ray diffraction technique and spectra analysis techniques were used to confirm the square planer geometry of the synthesized NPC's. Antimicrobial activity of the prepared 1,2,4-triazoles and their nickel complexes were studied which evaluated a high activity with complexes instead their triazoles.

1,2,4-TRIAZOLE, 1,3,4-OXADIAZOLE, AND 1,3,4-THIADIAZOLE DERIVATIVES AND THEIR ANTIMYCOBACTERIAL ACTIVITY

Disclosed herein are novel five membered heterocyclic compounds of Formula (I) wherein, X is S or SO2; n is 0, 1; m is1 or 2; Y is N, O or S; R2 independently represents H or alkyl or halo selected from -CI, -F; or -CF3, or -OH or-NH2 or - NO2; and R1 independently represents H or C1 to C5 straight or branched chain alkyl, alkenyl, alkynyl or a group -(CH2)5Br or pyrrolidine or - NHR' wherein R' is H or isopropyl or (II) or (III) which selectively act against dormant pathogenic tuberculi bacilli and exhibit antiproliferative activities and for treatment of a disease or disorder associated with GroEL1/GroEL2 activity. The invention relates to a process for preparation of novel five membered heterocyclic compounds of Formula I and to pharmaceutical compositions thereof.

The synthesis, X-ray crystal structure and optical properties of novel 1-ferrocenyl-2-(3-phenyl-1H-1,2,4-triazol-5-ylthio)ethanone derivatives

A series of novel 1-ferrocenyl-2-(3-phenyl-1H-1,2,4-triazol-5-ylthio)ethanone derivatives was synthesized by the reaction of 3-substituted-1H-1,2,4-triazole-5-thiol and chloroacetyl ferrocene in the presence of sodium hydride and potassium iodide at reflux. The structures of the new compounds were determined by IR and 1H NMR spectroscopy and HRMS. The structure of compound 5c was established by X-ray crystallography. UV-vis absorption and fluorescence spectra were recorded in ethanol and dichloromethane. The results showed that compounds 5a-g display similar absorptions ranging from 300 to 500 nm and maximal emission bands are about 566 nm. The intensity of fluorescence and maximal emission bands are dependent on the groups bonded to triazole rings.

5-Furan-2yl[1,3,4]oxadiazole-2-thiol, 5-furan-2yl-4h [1,2,4] triazole-3-thiol and their thiol-thione tautomerism

5-Furan-2-yl[1,3,4]oxadiazole-2-thiol (Ia) and 5-furan-2-yl-4H-[1,2,4]- triazole-3-thiol (Ib) were synthesized from furan-2-carboxylic acid hydrazide. Mannich bases and methyl derivatives were then prepared. The structures of the synthesized compounds were confirmed by elemental analyses, IR and 1H-NMR spectra. Their thiol-thione tautomeric equilibrium is described.

REACTIONS OF ARENECARBONYL ISOTHIOCYANATES WITH HYDRAZINE HYDRATE AND ARYLHYDRAZINES

This paper describes the preparation of 1,2,4-triazoline-5-thiones from arenecarbonyl isothiocyanates and hydrazine hydrate or arylhydrazines.The IR, UV and mass spectra are commented.