357979-06-7Relevant academic research and scientific papers
Pentadienyltitaniums as versatile intermediates: Regio- and stereoselectivities
Zellner,Schlosser
, p. 1016 - 1018 (2001)
The adduct obtained upon consecutive treatment of 1,4-dienes with butyllithium in the presence of potassium tert-butoxide, chlorotri(isopropyloxy)titanium and a carbonyl compound contains the α-hydroxyalkyl group invariably and exclusively linked to the 3-position of the former diene. When chlorotri(isopropyloxy)titanium is replaced by the Duthaler-Hafner reagent [(4R,5R)-chloro(cyclopentadienyl)(2,2-dimethyl-α,α,α ′,α′-tetraphenyl-1,3-dioxolane- 4,5-dimethanolato-O,Oα)titanium] the reaction does not only occur regioselectively but also with appreciably high enantioselectivity.
