358359-77-0

Upstream product

• 358359-58-7 2,3,5-tri-O-benzyl-D-arabinose dibenzyl dithioacetal 
• 89824-86-2 (2R,3R,4S)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-5-methoxytetrahydrofuran 
• 65-71-4 thymin 
• 378791-96-9 benzyl 2,3,5-tri-O-benzyl-1,4-dithio-L-xylofuranoside 

Downstream Products

• 6741-71-5 1-(4-thio-α, β-L-xylofuranosyl)thymine 

Relevant academic research and scientific papers

4'-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof

Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or acyl, Y is X, N3, NH2, monoalkylamino, or dialkylamino; Z is O or S; and X is selected from the group consisting o

Synthesis and biological activity of 4′-thio-L-xylofuranosyl nucleosides

A series of 4′-thio-L-xylofuranosyl nucleosides were prepared and evaluated as potential anticancer and antiviral agents. The details of a convenient and high-yielding synthesis of the carbohydrate precursor 1-O-acetyl-2,3,5-tri-O-benzyl-4- thio-L-xylofuranose (6) are presented. Proof of structure and configuration at all chiral centers of the nucleosides was obtained by proton and carbon NMR. All target compounds were evaluated in a series of human cancer cell lines in culture and as antiviral agents.