358366-78-6Relevant academic research and scientific papers
Synthetic studies on the synthesis of pyridine, α-pyran, α-thiopyran, and Thienothiopyranopyrrol derivatives using PTC technique
Khodairy,El-Sayed
, p. 475 - 486 (2001)
The reaction of p-chlorophenylmethylenemalononitrile 1 with some reactive halo compounds under phase-transfer catalysis conditions (PTC) afforded the corresponding alkylated or cyclized products 2-9 Thienothiopyranopyrrol 12a-c were synthesized from the reaction of compound 1 or 4 with CS2 and ethyl chloroacetate in 1:1:2 molar ratio via the formation of the intermediates thiopyrans 10a-c and theinothiopyrans 11a-c. Also, compound 1 or 4 reacted with phenylisocyanate or phenylisothiocyanate to give α-pyran, α-thiopyran pyridinone, and pyridine-2-thione derivatives 13-16, respectively. The sequence of the reactions was studied.
