358375-53-8

Upstream product

• 358375-55-0 1,1-dioxo-3-butyl-3-ethyl-5-phenyl-7-bromo-8-(ethoxycarbonylmethoxy)-2,3,4,5-tetrahydro-1,5-benzothiazepine 

Downstream Products

• 439088-08-1 1,1-Dioxo-3-butyl-3-ethyl-5-phenyl-7-isopropoxy-8-carboxymethoxy-2,3,4,5-tetrahydro-1,5-benzothiazepine 
• 439088-70-7 1,1-Dioxo-3-butyl-3-ethyl-5-phenyl-7-ethoxycarbonylmethylthio-8-carboxymethoxy-2,3,4,5-tetrahydro-1,5-benzothiazepine 

Relevant academic research and scientific papers

Chemical compounds

The present invention relates to compounds of the formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described. 1

1,5-Benzothiazepines and their use as hypolipidaemics

The present invention relates to compounds of formula (I) wherein R1 and R2 are independently selected from C1-6alkyl; one of R4 and R5 is a group of formula (IA): R3, R6, R